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RECRUITING Phase 2

A Study of Ranolazine in ALS

NCT06527222 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to evaluate safety, effect on cramps, function and quality of life of ranolazine versus placebo for the treatment of ALS.

Interventions

  • DRUG Placebo
  • DRUG Ranolazine

Study Locations (7)

Kansas

  • University of Kansas Medical Center — Fairway
  • University of Kansas Medical Center: Wichita — Wichita

California

  • University of California, San Francisco — San Francisco

Florida

  • Mayo Clinic Florida — Jacksonville

Missouri

  • University of Missouri Health Care — Columbia

Ohio

  • The Ohio State University — Columbus

Texas

  • National Neuromuscular Research Institute, PLLC. — Austin

Trial Details

FieldValue
Enrollment Target 72 participants
Start Date 2025-04-29
Est. Completion 2026-05
Phase Phase 2

Sponsor

Swathy Chandrashekhar, MBBS

1 total trials

Interested in This Trial?

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06527222

The ClinicalTrials.gov registry entry for NCT06527222 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 72 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Swathy Chandrashekhar, MBBS, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Amyotrophic Lateral Sclerosis appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06527222 reports 7 study locations spanning 6 distinct geographic areas — top geographies include Kansas, California, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06527222 about?

NCT06527222 is a clinical study titled "A Study of Ranolazine in ALS". The purpose of this study is to evaluate safety, effect on cramps, function and quality of life of ranolazine versus placebo for the treatment of ALS.

What is the current status of trial NCT06527222?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 72 participants. The study started on 2025-04-29. Estimated completion is 2026-05.

What conditions does trial NCT06527222 study?

This clinical trial studies the following conditions: Amyotrophic Lateral Sclerosis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06527222?

The interventions under investigation include: Placebo (DRUG), Ranolazine (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06527222?

This trial is sponsored by Swathy Chandrashekhar, MBBS, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06527222 being conducted?

This trial has 7 study locations across California, Florida, Kansas, Missouri, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial