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NCT06511544 · ClinicalTrials.gov registry record · NA
rTMS to Target Neural Connectivity and Rumination in Treatment-Resistant Depression
A NA study of Depression, Treatment Resistant, sponsored by Indiana University.
- Recruiting
- Registry status
- NA
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT06511544: Recruiting NA study of Depression, Treatment Resistant, sponsored by Indiana University.
NCT06511544 is a NA study of Depression, Treatment Resistant that is actively recruiting participants, run by Indiana University. The registered enrollment target is 20 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06511544, a NA study of Depression, Treatment Resistant, is actively recruiting participants, sponsored by Indiana University.
- RECRUITING
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to learn if Transcranial Magnetic Stimulation (TMS) to part of the brain called the ventromedial prefrontal cortex (VMPFC) can treat a symptom called rumination in adults with major depression that has not responded to at least one medication trial. The main question it aims to answer are: Does TMS to the VMPFC change brain activity on functional magnetic resonance imaging (fMRI) during a negative self-referential processing task in adults with depression? Does TMS to the VMPFC affect rumination in adults with depression? Researchers will compare brain scans and rumination scores before, during, and immediately after TMS. Participants will: Undergo three functional MRI scans Undergo a course of 20 TMS treatments Respond to clinical questionnaires and complete a computer behavioral task
Primary Outcome
Within-network functional connectivity of the default mode network during negative processing
Conditions Studied
Interventions
- DEVICE Transcranial magnetic stimulation
Study Locations (1)
Indiana
- Goodman Hall Neuroscience Center - Indianapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2024-01-02 |
| Est. Completion | 2026-06-30 |
| Phase | NA |
What NCT06511544 shows while recruiting
NCT06511544 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Depression, Treatment Resistant appearing as the primary indexed condition, and to 1 intervention - of which Transcranial magnetic stimulation is the first listed.
NCT06511544 reports a single indexed study location in Indiana.
Frequently Asked Questions
What is clinical trial NCT06511544 about?
NCT06511544 is a clinical study titled "rTMS to Target Neural Connectivity and Rumination in Treatment-Resistant Depression". The goal of this clinical trial is to learn if Transcranial Magnetic Stimulation (TMS) to part of the brain called the ventromedial prefrontal cortex (VMPFC) can treat a symptom called rumination in adults with major depression that has not responded to at least one medication trial. The main questi...
What is the current status of trial NCT06511544?
This trial is currently recruiting. It is a NA study. The enrollment target is 20 participants. The study started on 2024-01-02. Estimated completion is 2026-06-30.
What conditions does trial NCT06511544 study?
This clinical trial studies the following conditions: Depression, Treatment Resistant.
What interventions are being tested in trial NCT06511544?
The interventions under investigation include: Transcranial magnetic stimulation (DEVICE).
Who is sponsoring clinical trial NCT06511544?
This trial is sponsored by Indiana University, which has 890 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06511544 being conducted?
This trial has 1 study location across Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06511544's enrollment target sits among peer trials
20 1768th of 2000 higher than 140 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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