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NCT06499844 · ClinicalTrials.gov registry record · Early Phase 1
Comparing Approaches to Assess Nitric Oxide-dependent Cutaneous Vasodilation
A Early Phase 1 study of Endothelial Function, sponsored by University of Iowa.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 56
- Enrollment target
- 1
- Study location
NCT06499844 is a Early Phase 1 study of Endothelial Function that is actively recruiting participants, run by University of Iowa. The registered enrollment target is 56 participants, above the 21-participant average among 3 other Endothelial Function trials with a reported enrollment target (167% higher). The trial reports 1 study location across 1 state.
The verdict
NCT06499844, a Early Phase 1 study of Endothelial Function, is actively recruiting participants, sponsored by University of Iowa.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 56 participants
- Enrollment target
- 1
- Study location
Study Summary
The increase in skin blood flow in response to rapid local heating of the skin (i.e., cutaneous vasodilation) is commonly used to assess nitric oxide (NO)-dependent dilation and overall microvascular function. Historically, rapid local heating to 42°C was considered the standard approach for these assessments. More recently, many investigators have adopted rapid local to 39°C instead, based on its larger dependency on NO and therefore improved ability to quantify NO-dependent dilation without the use of pharmacological techniques. However, to date, only one direct methodological comparison between these protocols has been performed. In this study, the investigators use the blood vessels in the skin as a representative vascular bed for examining mechanisms of microvascular dysfunction in humans. Using a minimally invasive technique (intradermal microdialysis for the local delivery of pharmaceutical agents) they examine the blood vessels in a nickel-sized area of the skin in young adults ages 18 - 30 years old. Local heating of the skin at the microdialysis sites is used to explore differences in mechanisms governing microvascular control. As a compliment to these measurements, the investigators also have participants fill out a variety of surveys to assess things such as sleep quality, physical activity, daily stressors, etc.
Conditions Studied
Interventions
- DRUG Acetylcholine
Study Locations (1)
Iowa
- University of Iowa - Iowa City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 56 participants |
| Start Date | 2024-08-01 |
| Est. Completion | 2026-09 |
| Phase | Early Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06499844
The ClinicalTrials.gov registry entry for NCT06499844 describes a study currently listed as recruiting, categorized as Early Phase 1. The registered enrollment target is 56 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 21-participant average among 3 other Endothelial Function trials with a reported enrollment target (167% higher). The listed sponsor is University of Iowa, which has 228 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Endothelial Function appearing as the primary indexed condition, and to 1 intervention - of which Acetylcholine is the first listed.
NCT06499844 reports 1 study location spanning 1 distinct geographic area - top geographies include Iowa.
Frequently Asked Questions
What is clinical trial NCT06499844 about?
NCT06499844 is a clinical study titled "Comparing Approaches to Assess Nitric Oxide-dependent Cutaneous Vasodilation". The increase in skin blood flow in response to rapid local heating of the skin (i.e., cutaneous vasodilation) is commonly used to assess nitric oxide (NO)-dependent dilation and overall microvascular function. Historically, rapid local heating to 42°C was considered the standard approach for these a...
What is the current status of trial NCT06499844?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 56 participants. The study started on 2024-08-01. Estimated completion is 2026-09.
What conditions does trial NCT06499844 study?
This clinical trial studies the following conditions: Endothelial Function.
What interventions are being tested in trial NCT06499844?
The interventions under investigation include: Acetylcholine (DRUG).
Who is sponsoring clinical trial NCT06499844?
This trial is sponsored by University of Iowa, which has 228 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06499844 being conducted?
This trial has 1 study location across Iowa. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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