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NCT06448286 · ClinicalTrials.gov registry record · Phase 3
PH Weighted Chemical Exchange Saturation Transfer MRI-Based Surgical Resection to Improve Survival in Patients With Glioblastoma
A Phase 3 study, sponsored by Jonsson Comprehensive Cancer Center.
- Not yet
- Registry status
- Phase 3
- Development phase
- 60
- Enrollment target
NCT06448286 is a Phase 3 study that has not yet begun recruiting, run by Jonsson Comprehensive Cancer Center. The registered enrollment target is 60 participants.
The verdict
NCT06448286, a Phase 3 study, has not yet begun recruiting, sponsored by Jonsson Comprehensive Cancer Center.
- NOT YET RECRUITING
- Registry status
- Phase 3
- Development phase
- 60 participants
- Enrollment target
Study Summary
This phase III trial compares pH weighted chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI)-based surgical resections to standard of care surgical resections for the treatment of patients with glioblastoma. Standard of care therapy for glioblastoma is surgery to remove tumor tissue that enhances on standard MRI imaging, however, it has been shown that significant tumor burden exists in the region around the tumor tissue that does not enhance with standard MRI. MRI is a procedure in which radio waves and a powerful magnet linked to a computer are used to create detailed pictures of areas inside the body. These pictures can show the difference between normal and tumor tissue. CEST MRI is a technique that uses differences in the tissue environment, like protein concentration or intracellular pH, to generate contrast differences. CEST MRI may identify tumor tissue that does not enhance with standard of care MRI. PH weighted CEST MRI based surgical resection may be more effective compared to standard of care surgical resection in treating patients with glioblastoma.
Interventions
- PROCEDURE Magnetic Resonance Imaging
- RADIATION Radiation Therapy
- PROCEDURE Surgical Procedure
- PROCEDURE Contrast-enhanced Magnetic Resonance Imaging
- PROCEDURE Chemical Exchange Saturation Transfer Magnetic Resonance Imaging
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2026-12-01 |
| Est. Completion | 2031-12-01 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06448286
The ClinicalTrials.gov registry entry for NCT06448286 describes a study currently listed as not yet recruiting, categorized as Phase 3. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Jonsson Comprehensive Cancer Center, which has 321 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 5 interventions - of which Magnetic Resonance Imaging is the first listed.
NCT06448286 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT06448286 about?
NCT06448286 is a clinical study titled "PH Weighted Chemical Exchange Saturation Transfer MRI-Based Surgical Resection to Improve Survival in Patients With Glioblastoma". This phase III trial compares pH weighted chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI)-based surgical resections to standard of care surgical resections for the treatment of patients with glioblastoma. Standard of care therapy for glioblastoma is surgery to remove tu...
What is the current status of trial NCT06448286?
This trial is currently not yet recruiting. It is a Phase 3 study. The enrollment target is 60 participants. The study started on 2026-12-01. Estimated completion is 2031-12-01.
What interventions are being tested in trial NCT06448286?
The interventions under investigation include: Magnetic Resonance Imaging (PROCEDURE), Radiation Therapy (RADIATION), Surgical Procedure (PROCEDURE), Contrast-enhanced Magnetic Resonance Imaging (PROCEDURE), Chemical Exchange Saturation Transfer Magnetic Resonance Imaging (PROCEDURE).
Who is sponsoring clinical trial NCT06448286?
This trial is sponsored by Jonsson Comprehensive Cancer Center, which has 321 total clinical trials registered on ClinicalTrials.gov.
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