Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06448039 · ClinicalTrials.gov registry record · Phase 1
In-office Repair of Chronic Tympanic Membrane Perforations
A Phase 1 study, sponsored by D. Bradley Welling, MD, PhD.
- Active
- Registry status
- Phase 1
- Development phase
- 20
- Enrollment target
NCT06448039: Active Phase 1 study, sponsored by D. Bradley Welling, MD, PhD.
NCT06448039 is a Phase 1 study that is active but no longer recruiting, run by D. Bradley Welling, MD, PhD. The registered enrollment target is 20 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (67% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06448039, a Phase 1 study, is active but no longer recruiting, sponsored by D. Bradley Welling, MD, PhD.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 20 participants
- Enrollment target
Study Summary
The goal of this clinical trial is to compare the application of fibroblast growth factor 2 (FGF2) with normal saline for the healing of chronic tympanic membrane (TM) perforations. This is an extension of a prior study. The main question it aims to answer is: Will modifications to our prior surgical trial provide higher success rates in obtaining complete closure of chronic tympanic membrane perforations? Twenty participants will be randomized in a controlled study to FGF2 or saline in a 3:1 ratio and the total tympanic membrane closure compared.
Primary Outcome
Complete closure of tympanic membrane perforation by otoscopic examination and documented with photography
Interventions
- DRUG Fibroblast Growth Factor 2
- DRUG Saline control
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2024-06-15 |
| Est. Completion | 2026-12-30 |
| Phase | Phase 1 |
What the registry record for NCT06448039 still lists
NCT06448039 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (67% lower).
The record links to 0 conditions, and to 2 interventions - of which Fibroblast Growth Factor 2 is the first listed.
NCT06448039 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06448039 about?
NCT06448039 is a clinical study titled "In-office Repair of Chronic Tympanic Membrane Perforations". The goal of this clinical trial is to compare the application of fibroblast growth factor 2 (FGF2) with normal saline for the healing of chronic tympanic membrane (TM) perforations. This is an extension of a prior study. The main question it aims to answer is: Will modifications to our prior surgic...
What is the current status of trial NCT06448039?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2024-06-15. Estimated completion is 2026-12-30.
What interventions are being tested in trial NCT06448039?
The interventions under investigation include: Fibroblast Growth Factor 2 (DRUG), Saline control (DRUG).
Who is sponsoring clinical trial NCT06448039?
This trial is sponsored by D. Bradley Welling, MD, PhD, which has 3 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06448039's enrollment target sits among peer trials
20 1629th of 2000 higher than 285 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00573339 · 20 participants
Cardiac Magnetic Resonance Imaging (MRI) Normal Reference Control Group Testing
- NCT00692939 · 20 participants · Phase 1
Autologous Stem Cell Transplantation for Crohn's Disease
- NCT00967785 · 20 participants · Phase 1
A Phase I Study of Mozobil in the Treatment of Patients With WHIMS
- NCT01406691 · 20 participants · Phase 4
Light Flashes to Treat Delayed Sleep Phase Disorder (DSPD)
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI