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NCT06409819 · ClinicalTrials.gov registry record · Phase 1
Phage Therapy for Recurrent UTIs in Kidney Transplant Recipients
A Phase 1 study of Urinary Tract Infection, Recurrent, sponsored by University of California, San Diego.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 32
- Enrollment target
- 1
- Study location
NCT06409819 is a Phase 1 study of Urinary Tract Infection, Recurrent that is actively recruiting participants, run by University of California, San Diego. The registered enrollment target is 32 participants. The trial reports 1 study location across 1 state.
The verdict
NCT06409819, a Phase 1 study of Urinary Tract Infection, Recurrent, is actively recruiting participants, sponsored by University of California, San Diego.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 32 participants
- Enrollment target
- 1
- Study location
Study Summary
This proposal will take an important first step in the study of phage therapy for treatment of recurrent urinary tract infection (rUTI) in female kidney transplant recipients (KTR); a common condition that is associated with increasing multidrug resistance, sickness, loss of kidney function and death. The investigators will conduct a randomized phase I/II pilot clinical trial of targeted phage therapy versus placebo in asymptomatic female KTR with a history of rUTI due to Escherichia coli to assess safety, tolerability, and feasibility of this approach, possible efficacy, and changes in the gut and urinary microbiome during the 180 days of the study. This highly innovative and impactful proposal will provide proof of concept data and also inform the design of a subsequent larger phase III clinical trial of phage therapy for rUTI treatment in KTR and will have broad downstream effects within the fields of infectious diseases and transplantation.
Conditions Studied
Interventions
- DRUG phage therapy
- DRUG control
Study Locations (1)
California
- University of California, San Diego - La Jolla
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 32 participants |
| Start Date | 2025-06-15 |
| Est. Completion | 2027-03-01 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06409819
The ClinicalTrials.gov registry entry for NCT06409819 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 32 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of California, San Diego, which has 775 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Urinary Tract Infection, Recurrent appearing as the primary indexed condition, and to 2 interventions - of which phage therapy is the first listed.
NCT06409819 reports 1 study location spanning 1 distinct geographic area - top geographies include California.
Frequently Asked Questions
What is clinical trial NCT06409819 about?
NCT06409819 is a clinical study titled "Phage Therapy for Recurrent UTIs in Kidney Transplant Recipients". This proposal will take an important first step in the study of phage therapy for treatment of recurrent urinary tract infection (rUTI) in female kidney transplant recipients (KTR); a common condition that is associated with increasing multidrug resistance, sickness, loss of kidney function and deat...
What is the current status of trial NCT06409819?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 32 participants. The study started on 2025-06-15. Estimated completion is 2027-03-01.
What conditions does trial NCT06409819 study?
This clinical trial studies the following conditions: Urinary Tract Infection, Recurrent.
What interventions are being tested in trial NCT06409819?
The interventions under investigation include: phage therapy (DRUG), control (DRUG).
Who is sponsoring clinical trial NCT06409819?
This trial is sponsored by University of California, San Diego, which has 775 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06409819 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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