Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

COMPLETED Phase 2

Effects of NNC0194-0499, Cagrilintide, and Semaglutide Alone or in Combinations on Liver Damage and Alcohol Use in People With Alcohol-related Liver Disease

NCT06409130 · View on ClinicalTrials.gov ↗

Study Summary

The study will look at the effects of NNC0194-0499, cagrilintide and semaglutide, on liver damage and alcohol use in participants with alcoholic liver disease. Participants will get NNC0194-0499, semaglutide, cagrilintide or ''dummy" medicine in different treatment combinations. Which treatment participants get is decided by chance. The study will last for about 39 weeks.

Interventions

  • DRUG Semaglutide
  • DRUG NNC0194-0499
  • DRUG NNC0194-0499 placebo
  • DRUG Semaglutide placebo (Group A)
  • DRUG Cagrilintide + semaglutide

Study Locations (20)

Florida

  • Covenant Metabolic Specialists LLC — Fort Myers
  • Miguel Rebollar PA — Hialeah
  • UF Hlth Jacksonville — Jacksonville
  • Univ of Miami/Schiff Ctr — Miami
  • Covenant Metabolic Specialists LLC — University Park

Arizona

  • The Institute for Liver Health — Chandler
  • Arizona Liver Center — Tucson
  • Del Sol Research Management, LLC — Tucson

California

  • OM Research LLC — Lancaster
  • California Liver Research Institute — Pasadena

Pennsylvania

  • University of Pennsylvania Hospital — Philadelphia
  • UPMC_Center for Liver Care — Pittsburgh

Illinois

  • Rush University Med. Cntr — Chicago

Kansas

  • Kansas Medical Clinic, PA — Topeka

Louisiana

  • Louisiana Research Center, LLC — Shreveport

Massachusetts

  • Boston Medical Center_Cary — Boston

Trial Details

FieldValue
Enrollment Target 270 participants
Start Date 2024-05-20
Est. Completion 2026-01-12
Phase Phase 2

Sponsor

Novo Nordisk A/S

189 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06409130

The ClinicalTrials.gov registry entry for NCT06409130 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 270 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Novo Nordisk A/S, which has 189 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Alcohol-related Liver Disease appearing as the primary indexed condition, and to 5 interventions — of which Semaglutide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06409130 reports 20 study locations spanning 12 distinct geographic areas — top geographies include Florida, Arizona, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06409130 about?

NCT06409130 is a clinical study titled "Effects of NNC0194-0499, Cagrilintide, and Semaglutide Alone or in Combinations on Liver Damage and Alcohol Use in People With Alcohol-related Liver Disease". The study will look at the effects of NNC0194-0499, cagrilintide and semaglutide, on liver damage and alcohol use in participants with alcoholic liver disease. Participants will get NNC0194-0499, semaglutide, cagrilintide or ''dummy" medicine in different treatment combinations. Which treatment part...

What is the current status of trial NCT06409130?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 270 participants. The study started on 2024-05-20. Estimated completion is 2026-01-12.

What conditions does trial NCT06409130 study?

This clinical trial studies the following conditions: Alcohol-related Liver Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06409130?

The interventions under investigation include: Semaglutide (DRUG), NNC0194-0499 (DRUG), NNC0194-0499 placebo (DRUG), Semaglutide placebo (Group A) (DRUG), Cagrilintide + semaglutide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06409130?

This trial is sponsored by Novo Nordisk A/S, which has 189 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06409130 being conducted?

This trial has 20 study locations across Arizona, California, Florida, Illinois, Kansas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial