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NCT06406777 · ClinicalTrials.gov registry record · Phase 1
Chronic Lung Allograft Dysfunction MRI Study
A Phase 1 study of Chronic Lung Allograft Dysfunction Lung MRI (CLAD), sponsored by Sean Fain.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 100
- Enrollment target
- 1
- Study location
NCT06406777: Recruiting Phase 1 study of Chronic Lung Allograft Dysfunction Lung MRI (CLAD), sponsored by Sean Fain.
NCT06406777 is a Phase 1 study of Chronic Lung Allograft Dysfunction Lung MRI (CLAD) that is actively recruiting participants, run by Sean Fain. The registered enrollment target is 100 participants, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (67% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06406777, a Phase 1 study of Chronic Lung Allograft Dysfunction Lung MRI (CLAD), is actively recruiting participants, sponsored by Sean Fain.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
This studies purpose is to confirm the efficacy and efficiency of using OE-MRI and MRI with hyperpolarized gas techniques and Iodinated contrast CT scan, this will enhance understanding of CLAD pathophysiology. Moreover, this project is foundational to performing additional studies to establish if novel MRI imaging can serve as an objective confirmatory diagnostic tool for CLAD in post-transplant patients.
Primary Outcome
Absolute decrease of FEV1 by 20%
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Spirometry
- DIAGNOSTIC_TEST Contrast Lung Computed Tomography (CT) Scan
- DIAGNOSTIC_TEST Oxygen enhanced magnetic resonance imaging (OE-MRI) Scan
- DRUG 129Xe MRI scans
Study Locations (1)
Iowa
- University of Iowa - Iowa City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2025-03-20 |
| Est. Completion | 2028-09 |
| Phase | Phase 1 |
What NCT06406777 shows while recruiting
NCT06406777 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (67% higher).
The record links to 1 condition, with Chronic Lung Allograft Dysfunction Lung MRI (CLAD) appearing as the primary indexed condition, and to 4 interventions - of which Spirometry is the first listed.
NCT06406777 reports a single indexed study location in Iowa.
Frequently Asked Questions
What is clinical trial NCT06406777 about?
NCT06406777 is a clinical study titled "Chronic Lung Allograft Dysfunction MRI Study". This studies purpose is to confirm the efficacy and efficiency of using OE-MRI and MRI with hyperpolarized gas techniques and Iodinated contrast CT scan, this will enhance understanding of CLAD pathophysiology. Moreover, this project is foundational to performing additional studies to establish if n...
What is the current status of trial NCT06406777?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 100 participants. The study started on 2025-03-20. Estimated completion is 2028-09.
What conditions does trial NCT06406777 study?
This clinical trial studies the following conditions: Chronic Lung Allograft Dysfunction Lung MRI (CLAD).
What interventions are being tested in trial NCT06406777?
The interventions under investigation include: Spirometry (DIAGNOSTIC_TEST), Contrast Lung Computed Tomography (CT) Scan (DIAGNOSTIC_TEST), Oxygen enhanced magnetic resonance imaging (OE-MRI) Scan (DIAGNOSTIC_TEST), 129Xe MRI scans (DRUG).
Who is sponsoring clinical trial NCT06406777?
This trial is sponsored by Sean Fain, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06406777 being conducted?
This trial has 1 study location across Iowa. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06406777's enrollment target sits among peer trials
100 546th of 2000 higher than 1,411 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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