Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06374290 · ClinicalTrials.gov registry record · Phase 1
Study of Injectable Naltrexone and Oral Bupropion Among Cigarette Smokers With Schizophrenia
A Phase 1 study, sponsored by The University of Texas Health Science Center, Houston.
- Terminated
- Registry status
- Phase 1
- Development phase
- 2
- Enrollment target
NCT06374290: Clinical Trial Phase 1 study, sponsored by The University of Texas Health Science Center, Houston.
NCT06374290 is a Phase 1 study that was terminated before completion, run by The University of Texas Health Science Center, Houston. The registered enrollment target is 2 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06374290, a Phase 1 study, was terminated before completion, sponsored by The University of Texas Health Science Center, Houston.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 2 participants
- Enrollment target
Study Summary
The purpose of this study is to assess the feasibility and safety of injectable naltrexone (NTX;380 mg) in conjunction with oral bupropion (BUP; 450 mg daily)NTX-BUP administration among individuals with schizophrenia spectrum disorders that smoke cigarettes and to evaluate change on smoking-related measures and symptoms of schizophrenia.
Interventions
- DRUG Bupropion
- DRUG Naltrexone (Vivitrol)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2 participants |
| Start Date | 2024-07-16 |
| Est. Completion | 2024-12-04 |
| Phase | Phase 1 |
Why NCT06374290 stopped before completion
NCT06374290 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 2 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 2 interventions - of which Bupropion is the first listed.
NCT06374290 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06374290 about?
NCT06374290 is a clinical study titled "Study of Injectable Naltrexone and Oral Bupropion Among Cigarette Smokers With Schizophrenia". The purpose of this study is to assess the feasibility and safety of injectable naltrexone (NTX;380 mg) in conjunction with oral bupropion (BUP; 450 mg daily)NTX-BUP administration among individuals with schizophrenia spectrum disorders that smoke cigarettes and to evaluate change on smoking-related...
What is the current status of trial NCT06374290?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 2 participants. The study started on 2024-07-16. Estimated completion is 2024-12-04.
What interventions are being tested in trial NCT06374290?
The interventions under investigation include: Bupropion (DRUG), Naltrexone (Vivitrol) (DRUG).
Who is sponsoring clinical trial NCT06374290?
This trial is sponsored by The University of Texas Health Science Center, Houston, which has 732 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06374290's enrollment target sits among peer trials
2 2000th of 2000 the lowest of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI