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ACTIVE NOT RECRUITING Phase 3

Study to Compare the Effectiveness and Safety of Golcadomide Plus R-CHOP vs Placebo Plus R-CHOP in Participants With Previously Untreated High-risk Large B-cell Lymphoma

NCT06356129 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to compare the effectiveness and safety of golcadomide in combination with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy vs placebo in combination with R-CHOP chemotherapy in participants with previously untreated high-risk large B-cell lymphoma (LBCL).

Conditions Studied

Interventions

  • DRUG Cyclophosphamide
  • DRUG Placebo
  • DRUG Doxorubicin
  • DRUG Rituximab
  • DRUG Golcadomide

Study Locations (20)

Florida

  • Local Institution - 0497 — Fort Myers
  • Local Institution - 0287 — Jacksonville
  • Local Institution - 0415 — Margate
  • Local Institution - 0045 — Miami Beach
  • Local Institution - 0012 — Pensacola
  • Local Institution - 0502 — St. Petersburg
  • Local Institution - 0414 — Tampa
  • Local Institution - 0192 — West Palm Beach
  • Local Institution - 0485 — Weston

Georgia

  • Local Institution - 0515 — Atlanta
  • Local Institution - 0303 — Atlanta

Illinois

  • Local Institution - 0182 — Chicago
  • Local Institution - 0048 — Skokie

Alabama

  • Local Institution - 0014 — Mobile

Alaska

  • Local Institution - 0477 — Anchorage

Arizona

  • Local Institution - 0452 — Phoenix

California

  • Local Institution - 0342 — San Francisco

Iowa

  • Local Institution - 0461 — Waukee

Trial Details

FieldValue
Enrollment Target 850 participants
Start Date 2024-06-19
Est. Completion 2029-11-20
Phase Phase 3

Sponsor

Celgene

73 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06356129

The ClinicalTrials.gov registry entry for NCT06356129 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 850 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Celgene, which has 73 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Large B-cell Lymphoma appearing as the primary indexed condition, and to 5 interventions — of which Cyclophosphamide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06356129 reports 20 study locations spanning 10 distinct geographic areas — top geographies include Florida, Georgia, Illinois. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06356129 about?

NCT06356129 is a clinical study titled "Study to Compare the Effectiveness and Safety of Golcadomide Plus R-CHOP vs Placebo Plus R-CHOP in Participants With Previously Untreated High-risk Large B-cell Lymphoma". The purpose of this study is to compare the effectiveness and safety of golcadomide in combination with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy vs placebo in combination with R-CHOP chemotherapy in participants with previously untreated high-risk l...

What is the current status of trial NCT06356129?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 850 participants. The study started on 2024-06-19. Estimated completion is 2029-11-20.

What conditions does trial NCT06356129 study?

This clinical trial studies the following conditions: Large B-cell Lymphoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06356129?

The interventions under investigation include: Cyclophosphamide (DRUG), Placebo (DRUG), Doxorubicin (DRUG), Rituximab (DRUG), Golcadomide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06356129?

This trial is sponsored by Celgene, which has 73 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06356129 being conducted?

This trial has 20 study locations across Alabama, Alaska, Arizona, California, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial