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NCT06335953 · ClinicalTrials.gov registry record · NA
ALIGN: Aligning Medications With What Matters Most (Demonstration)
A NA study, sponsored by Johns Hopkins University.
- Completed
- Registry status
- NA
- Development phase
- 360
- Enrollment target
NCT06335953: Completed NA study, sponsored by Johns Hopkins University.
NCT06335953 is a NA study that has completed, run by Johns Hopkins University. The registered enrollment target is 360 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (74% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06335953, a NA study, has completed, sponsored by Johns Hopkins University.
- COMPLETED
- Registry status
- NA
- Development phase
- 360 participants
- Enrollment target
Study Summary
The goal of this clinical trial is to test the effectiveness of a pharmacist-led, primary care-based de-prescribing intervention for people living with dementia (PLWD) and the person's care partners. The intervention consists of the following strategies: 1) a de-prescribing educational brochure designed to activate the patient and care partner; 2) a single telehealth visit in which an embedded clinical pharmacist discusses the benefits and harms of the patient's medications with the patient and care partner in the context of the person's goals and preferences; and 3) pharmacist-PCP communication in which the pharmacist provides tailored de-prescribing recommendations designed to be useful and actionable for the PCP. The investigators will compare the intervention group with the waitlist control group to see if there is a difference in the primary outcome, the proportion of patients who deprescribe at least one medication by 3 months.
Primary Outcome
The primary outcome for the study will be the patients who stop ≥1 medication, assessed at 3 months, analyzed per protocol and reported as count of participants. Discontinuation will be defined as a medication that is listed on the medication list at one time point and not listed at the subsequent time point. Discontinued medications will be measured using data obtained from the Electronic Health Record (EHR).
Interventions
- BEHAVIORAL Pharmacist-led deprescribing intervention
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 360 participants |
| Start Date | 2024-05-07 |
| Est. Completion | 2025-10-18 |
| Phase | NA |
What the finished NCT06335953 record still lists
NCT06335953 is an interventional study that assigns participants to a tested intervention. The registered 360 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (74% lower).
The record links to 0 conditions, and to 1 intervention - of which Pharmacist-led deprescribing intervention is the first listed.
NCT06335953 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06335953 about?
NCT06335953 is a clinical study titled "ALIGN: Aligning Medications With What Matters Most (Demonstration)". The goal of this clinical trial is to test the effectiveness of a pharmacist-led, primary care-based de-prescribing intervention for people living with dementia (PLWD) and the person's care partners. The intervention consists of the following strategies: 1) a de-prescribing educational brochure des...
What is the current status of trial NCT06335953?
This trial is currently completed. It is a NA study. The enrollment target is 360 participants. The study started on 2024-05-07. Estimated completion is 2025-10-18.
What interventions are being tested in trial NCT06335953?
The interventions under investigation include: Pharmacist-led deprescribing intervention (BEHAVIORAL).
Who is sponsoring clinical trial NCT06335953?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06335953's enrollment target sits among peer trials
360 284th of 2000 higher than 1,713 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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