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NCT06305091 · ClinicalTrials.gov registry record
DNA Methylation Markers in Veterans Exposed to Open Burn Pits
A clinical trial of Open Burn Pit Exposure, sponsored by Central Arkansas Veterans Healthcare System.
- Recruiting
- Registry status
- 330
- Enrollment target
- 1
- Study location
NCT06305091: Recruiting study of Open Burn Pit Exposure, sponsored by Central Arkansas Veterans Healthcare System.
NCT06305091 is a study of Open Burn Pit Exposure that is actively recruiting participants, run by Central Arkansas Veterans Healthcare System. The registered enrollment target is 330 participants. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06305091, a study of Open Burn Pit Exposure, is actively recruiting participants, sponsored by Central Arkansas Veterans Healthcare System.
- RECRUITING
- Registry status
- 330 participants
- Enrollment target
- 1
- Study location
Study Summary
Background: The VA and DoD estimate that 3.5 million Veterans and Service Members were exposed to open burn pits used for waste disposal during military deployments to countries such as Kuwait, Afghanistan, and Iraq since 1990. Since the lasting adverse effects of this exposure on health are unknown, the VA Airborne Hazards and Open Burn Pit Registry (AHOBPR) was created. More than 209,000 participants to date have answered the registry questionnaire about the extent of exposure to burn pits and other airborne hazards. The questions attempted to quantify the duration of exposure, the severity of acute health effects, and the relative timing of onset or worsening of chronic respiratory, cardiovascular, neurological, and other illnesses. However, the AHOBPR interview lacks specific inquiry about mental health and biomarkers. The proposed study will recruit AHOBPR participants and non-participant for a follow-up enhanced evaluation of their health in a translational research study to better characterize their psychological, physical health profile, and potentially harmful epigenetic and biochemical exposure-related alterations. Hypothesis: The investigators hypothesize that 1) the severity of individual exposure to burn pits will be positively correlated with levels of persistent organic pollutants in blood and metals in urine and specific epigenetic alterations in DNA methylation; and 2) levels of toxic chemicals and alterations in the methylation of specific genes will be positively correlated with chronic problems involving the cardiovascular, respiratory, neuropsychiatric and other systems. Specific Aims: (1) Describe and quantify relationships of the intensity and duration of exposure with persistent organic chemicals/metals in the registry participants and ascertain their relationships with health outcomes linked to burn pit exposure. (2) Discover and validate DNA methylation marks that best distinguish between individuals exposed to burn pits and those not; th
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Health survey for physical and mental health comorbidities, epigenetic marker and heavy metals in blood and urine samples
Study Locations (1)
Arkansas
- Central Arkansas Veterans Healthcare System (3J/NLR) - North Little Rock
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 330 participants |
| Start Date | 2023-03-13 |
| Est. Completion | 2027-03-31 |
What NCT06305091 shows while recruiting
NCT06305091 is an observational study that tracks outcomes without assigning an intervention. The registered 330 participants enrollment target is mid-sized for trials with a published cap.
The record links to 1 condition, with Open Burn Pit Exposure appearing as the primary indexed condition, and to 1 intervention - of which Health survey for physical and mental health comorbidities, epigenetic marker and heavy metals in blood and urine samples is the first listed.
NCT06305091 reports a single indexed study location in Arkansas.
Frequently Asked Questions
What is clinical trial NCT06305091 about?
NCT06305091 is a clinical study titled "DNA Methylation Markers in Veterans Exposed to Open Burn Pits". Background: The VA and DoD estimate that 3.5 million Veterans and Service Members were exposed to open burn pits used for waste disposal during military deployments to countries such as Kuwait, Afghanistan, and Iraq since 1990. Since the lasting adverse effects of this exposure on health are unknown...
What is the current status of trial NCT06305091?
This trial is currently recruiting. The enrollment target is 330 participants. The study started on 2023-03-13. Estimated completion is 2027-03-31.
What conditions does trial NCT06305091 study?
This clinical trial studies the following conditions: Open Burn Pit Exposure.
What interventions are being tested in trial NCT06305091?
The interventions under investigation include: Health survey for physical and mental health comorbidities, epigenetic marker and heavy metals in blood and urine samples (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT06305091?
This trial is sponsored by Central Arkansas Veterans Healthcare System, which has 9 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06305091 being conducted?
This trial has 1 study location across Arkansas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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