Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06299592 · ClinicalTrials.gov registry record
Comparison of Microglial Activation in Severe Asthma and Healthy Controls
A clinical trial of Asthma, sponsored by University of Wisconsin, Madison.
- Recruiting
- Registry status
- 100
- Enrollment target
- 1
- Study location
NCT06299592: Recruiting study of Asthma, sponsored by University of Wisconsin, Madison.
NCT06299592 is a study of Asthma that is actively recruiting participants, run by University of Wisconsin, Madison. The registered enrollment target is 100 participants, below the 1,563-participant average among 374 other Asthma trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06299592, a study of Asthma, is actively recruiting participants, sponsored by University of Wisconsin, Madison.
- RECRUITING
- Registry status
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to learn about how asthma influences brain function. The main questions it aims to answer are: * How airway inflammation in asthma affects the brain; and, * Whether airway inflammation in asthma is related to symptoms of depression and anxiety Over the course of 3 visits, participants will: * Complete questionnaires * Complete computer tasks * Undergo allergy skin test and breathing tests * Give two blood samples * Give a sputum sample * Complete brain imaging scans Researchers will compare results between participants with asthma, and participants who do not have asthma.
Primary Outcome
A whole-brain voxel-wise t-test will be performed in FMRIB Software Library (FSL) to identify regions where \[18F\]-FEPPA binding is significantly different between groups.
Conditions Studied
Interventions
- COMBINATION_PRODUCT PET/MRI using [18F]FEPPA tracer
Study Locations (1)
Wisconsin
- Center for Healthy Minds - Madison
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2024-03-06 |
| Est. Completion | 2028-08 |
What NCT06299592 shows while recruiting
NCT06299592 is an observational study that tracks outcomes without assigning an intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 1,563-participant average among 374 other Asthma trials with a reported enrollment target (94% lower).
The record links to 1 condition, with Asthma appearing as the primary indexed condition, and to 1 intervention - of which PET/MRI using [18F]FEPPA tracer is the first listed.
NCT06299592 reports a single indexed study location in Wisconsin.
Frequently Asked Questions
What is clinical trial NCT06299592 about?
NCT06299592 is a clinical study titled "Comparison of Microglial Activation in Severe Asthma and Healthy Controls". The goal of this clinical trial is to learn about how asthma influences brain function. The main questions it aims to answer are: * How airway inflammation in asthma affects the brain; and, * Whether airway inflammation in asthma is related to symptoms of depression and anxiety Over the course of ...
What is the current status of trial NCT06299592?
This trial is currently recruiting. The enrollment target is 100 participants. The study started on 2024-03-06. Estimated completion is 2028-08.
What conditions does trial NCT06299592 study?
This clinical trial studies the following conditions: Asthma.
What interventions are being tested in trial NCT06299592?
The interventions under investigation include: PET/MRI using [18F]FEPPA tracer (COMBINATION_PRODUCT).
Who is sponsoring clinical trial NCT06299592?
This trial is sponsored by University of Wisconsin, Madison, which has 1,039 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06299592 being conducted?
This trial has 1 study location across Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Asthma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06299592's enrollment target sits among peer trials
100 211th of 374 higher than 160 of 374 other Asthma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Asthma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Innate Immunity in Allergic Asthma
RECRUITING
-
Automated Inhaler Monitoring for Asthma Medication Usage
RECRUITING · NA
-
Impact of Metabolic Dysfunction and Mucus Plugging on Asthma Physiology
RECRUITING
-
Depemokimab Asthma Imaging and Bronchoscopy Sub-Study
RECRUITING · Phase 3
-
Escitalopram in Asthma Patients With Frequent Exacerbation
RECRUITING · Phase 2
-
Measuring the Effect of Dupilumab Treatment on Mucociliary Clearance (MCC) in Subjects With Moderate to Severe Asthma
RECRUITING · Phase 4
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01048281 · 100 participants
Clinical & Pathological Studies of Upper Gastrointestinal Carcinoma
- NCT01161199 · 100 participants
The Use of Leukapheresis to Support HIV Pathogenesis Studies
- NCT01327690 · 100 participants · Early Phase 1
Mental Health in Veterans and Families After Group Therapies
- NCT01730781 · 100 participants
Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI