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NCT06280274 · ClinicalTrials.gov registry record · Phase 4
Metformin Use in Patients Undergoing Total Joint Replacement Surgery
A Phase 4 study, sponsored by Oregon Health and Science University.
- Completed
- Registry status
- Phase 4
- Development phase
- 40
- Enrollment target
NCT06280274: Completed Phase 4 study, sponsored by Oregon Health and Science University.
NCT06280274 is a Phase 4 study that has completed, run by Oregon Health and Science University. The registered enrollment target is 40 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (92% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06280274, a Phase 4 study, has completed, sponsored by Oregon Health and Science University.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 40 participants
- Enrollment target
Study Summary
The goal of this pilot, randomized, single-blind, placebo-controlled trial is to evaluate the feasibility of and provide preliminary information for a multi-center randomized controlled trial that will assess the effects of metformin on blood sugar control in patients after total hip or total knee replacement surgery. The primary objective of this study is to assess the feasibility of conducting a large, randomized trial with regards to timely recruitment, study drug administration, protocol adherence, and overall retention in patients undergoing total joint arthroplasty. Secondarily, the investigators aim to obtain preliminary estimates of group-specific outcome means and variances for primary and secondary outcomes of a larger future trial.
Primary Outcome
Feasibility defined by an average of four participants per month successfully enrolled and randomized.
Interventions
- OTHER Placebo
- DRUG Metformin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2024-06-27 |
| Est. Completion | 2025-09-15 |
| Phase | Phase 4 |
What the finished NCT06280274 record still lists
NCT06280274 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (92% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT06280274 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06280274 about?
NCT06280274 is a clinical study titled "Metformin Use in Patients Undergoing Total Joint Replacement Surgery". The goal of this pilot, randomized, single-blind, placebo-controlled trial is to evaluate the feasibility of and provide preliminary information for a multi-center randomized controlled trial that will assess the effects of metformin on blood sugar control in patients after total hip or total knee r...
What is the current status of trial NCT06280274?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 40 participants. The study started on 2024-06-27. Estimated completion is 2025-09-15.
What interventions are being tested in trial NCT06280274?
The interventions under investigation include: Placebo (OTHER), Metformin (DRUG).
Who is sponsoring clinical trial NCT06280274?
This trial is sponsored by Oregon Health and Science University, which has 546 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06280274's enrollment target sits among peer trials
40 1397th of 2000 higher than 533 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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