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NCT06242847 · ClinicalTrials.gov registry record
Role of Insulin Action in Psoriasis Pathogenesis
A clinical trial, sponsored by Columbia University.
- Terminated
- Registry status
- 10
- Enrollment target
NCT06242847: Clinical Trial study, sponsored by Columbia University.
NCT06242847 is a clinical trial that was terminated before completion, run by Columbia University. The registered enrollment target is 10 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06242847 was terminated before completion, sponsored by Columbia University.
- TERMINATED
- Registry status
- 10 participants
- Enrollment target
Study Summary
The goal of this study is to collect more information from people with plaque psoriasis and to determine if insulin plays a role in the pathogenesis of psoriasis. The main question it aims to answer is if insulin action is preserved or even enhanced in psoriatic lesions despite insulin resistance elsewhere. Participants with plaque psoriasis will have punch biopsies taken of lesional and non-lesional skin after an overnight fast and then during an oral glucose tolerance test. Biopsy specimens will then be assessed for markers of insulin action.
Primary Outcome
Investigators will perform Western blots on skin biopsies using antibodies to phosphorylated (T308, S473) and total AKT. The ratio of phosphorylated to total AKT will be determined using densitometry of Western blots and/or by enzyme-linked immunosorbent assays (ELISA), each measured in arbitrary units (AU).
Interventions
- PROCEDURE Skin punch biopsy
- DIAGNOSTIC_TEST Oral glucose tolerance test (OGTT)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2024-02-02 |
| Est. Completion | 2025-11-12 |
Why NCT06242847 stopped before completion
NCT06242847 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 10 participants, a relatively small participant target.
The record links to 0 conditions, and to 2 interventions - of which Skin punch biopsy is the first listed.
NCT06242847 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06242847 about?
NCT06242847 is a clinical study titled "Role of Insulin Action in Psoriasis Pathogenesis". The goal of this study is to collect more information from people with plaque psoriasis and to determine if insulin plays a role in the pathogenesis of psoriasis. The main question it aims to answer is if insulin action is preserved or even enhanced in psoriatic lesions despite insulin resistance el...
What is the current status of trial NCT06242847?
This trial is currently terminated. The enrollment target is 10 participants. The study started on 2024-02-02. Estimated completion is 2025-11-12.
What interventions are being tested in trial NCT06242847?
The interventions under investigation include: Skin punch biopsy (PROCEDURE), Oral glucose tolerance test (OGTT) (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT06242847?
This trial is sponsored by Columbia University, which has 958 total clinical trials registered on ClinicalTrials.gov.
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