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NCT06233344 · ClinicalTrials.gov registry record · Phase 2
Mindfulness-assisted Psychedelic Therapy
A Phase 2 study of Mental Health, sponsored by University of Southern California.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT06233344: Recruiting Phase 2 study of Mental Health, sponsored by University of Southern California.
NCT06233344 is a Phase 2 study of Mental Health that is actively recruiting participants, run by University of Southern California. The registered enrollment target is 40 participants, below the 10,183-participant average among 62 other Mental Health trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06233344, a Phase 2 study of Mental Health, is actively recruiting participants, sponsored by University of Southern California.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to test psilocybin in combination with mindfulness training in healthy adults. The main question it aims to answer is "Does mindfulness training enhance the effects of psychedelic therapy (psilocybin) on mental health?" Interested individuals will complete an initial eligibility session and eligible participants will then be randomized into one of two groups: one dose of psilocybin (administered under the supervision of study therapists) combined with 8 weeks of weekly mindfulness training classes (Arm 1) or psilocybin alone (Arm 2). Both groups will complete baseline and post-treatment assessment sessions where they will complete questionnaires, computerized cognitive tests, and have an EEG (a measure of electrical activity in the brain). Both groups will also complete 2 follow-up surveys (at 8 weeks and 1 year after the post-treatment assessment) either online through REDCap or by phone or video call with a research assistant.
Primary Outcome
The primary feasibility outcome will be participant retention (percent of eligible enrolled participants who complete the 8-week follow-up session)
Conditions Studied
Interventions
- DRUG Psilocybin
- DRUG Psilocybin plus mindfulness training
Study Locations (1)
California
- Univeristy of Southern California Brain and Creativity Institute - Los Angeles
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2025-07-30 |
| Est. Completion | 2027-08 |
| Phase | Phase 2 |
What NCT06233344 shows while recruiting
NCT06233344 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 10,183-participant average among 62 other Mental Health trials with a reported enrollment target (100% lower).
The record links to 1 condition, with Mental Health appearing as the primary indexed condition, and to 2 interventions - of which Psilocybin is the first listed.
NCT06233344 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT06233344 about?
NCT06233344 is a clinical study titled "Mindfulness-assisted Psychedelic Therapy". The goal of this clinical trial is to test psilocybin in combination with mindfulness training in healthy adults. The main question it aims to answer is "Does mindfulness training enhance the effects of psychedelic therapy (psilocybin) on mental health?" Interested individuals will complete an initi...
What is the current status of trial NCT06233344?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 40 participants. The study started on 2025-07-30. Estimated completion is 2027-08.
What conditions does trial NCT06233344 study?
This clinical trial studies the following conditions: Mental Health.
What interventions are being tested in trial NCT06233344?
The interventions under investigation include: Psilocybin (DRUG), Psilocybin plus mindfulness training (DRUG).
Who is sponsoring clinical trial NCT06233344?
This trial is sponsored by University of Southern California, which has 617 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06233344 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Mental Health
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06233344's enrollment target sits among peer trials
40 59th of 62 higher than 3 of 62 other Mental Health trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Mental Health trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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