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NCT06233344 · ClinicalTrials.gov registry record · Phase 2

Mindfulness-assisted Psychedelic Therapy

A Phase 2 study of Mental Health, sponsored by University of Southern California.

Recruiting
Registry status
Phase 2
Development phase
40
Enrollment target
1
Study location

NCT06233344 is a Phase 2 study of Mental Health that is actively recruiting participants, run by University of Southern California. The registered enrollment target is 40 participants, below the 10,183-participant average among 62 other Mental Health trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06233344, a Phase 2 study of Mental Health, is actively recruiting participants, sponsored by University of Southern California.

RECRUITING
Registry status
Phase 2
Development phase
40 participants
Enrollment target
1
Study location

Study Summary

The goal of this clinical trial is to test psilocybin in combination with mindfulness training in healthy adults. The main question it aims to answer is "Does mindfulness training enhance the effects of psychedelic therapy (psilocybin) on mental health?" Interested individuals will complete an initial eligibility session and eligible participants will then be randomized into one of two groups: one dose of psilocybin (administered under the supervision of study therapists) combined with 8 weeks of weekly mindfulness training classes (Arm 1) or psilocybin alone (Arm 2). Both groups will complete baseline and post-treatment assessment sessions where they will complete questionnaires, computerized cognitive tests, and have an EEG (a measure of electrical activity in the brain). Both groups will also complete 2 follow-up surveys (at 8 weeks and 1 year after the post-treatment assessment) either online through REDCap or by phone or video call with a research assistant.

Conditions Studied

Mental Health

Interventions

  • DRUG Psilocybin
  • DRUG Psilocybin plus mindfulness training

Study Locations (1)

California

  • Univeristy of Southern California Brain and Creativity Institute - Los Angeles

Trial Details

FieldValue
Enrollment Target 40 participants
Start Date 2025-07-30
Est. Completion 2027-08
Phase Phase 2

Sponsor

University of Southern California

617 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06233344

The ClinicalTrials.gov registry entry for NCT06233344 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 40 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 10,183-participant average among 62 other Mental Health trials with a reported enrollment target (100% lower). The listed sponsor is University of Southern California, which has 617 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Mental Health appearing as the primary indexed condition, and to 2 interventions - of which Psilocybin is the first listed.

NCT06233344 reports 1 study location spanning 1 distinct geographic area - top geographies include California.

Frequently Asked Questions

What is clinical trial NCT06233344 about?

NCT06233344 is a clinical study titled "Mindfulness-assisted Psychedelic Therapy". The goal of this clinical trial is to test psilocybin in combination with mindfulness training in healthy adults. The main question it aims to answer is "Does mindfulness training enhance the effects of psychedelic therapy (psilocybin) on mental health?" Interested individuals will complete an initi...

What is the current status of trial NCT06233344?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 40 participants. The study started on 2025-07-30. Estimated completion is 2027-08.

What conditions does trial NCT06233344 study?

This clinical trial studies the following conditions: Mental Health.

What interventions are being tested in trial NCT06233344?

The interventions under investigation include: Psilocybin (DRUG), Psilocybin plus mindfulness training (DRUG).

Who is sponsoring clinical trial NCT06233344?

This trial is sponsored by University of Southern California, which has 617 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06233344 being conducted?

This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.