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NCT06214468 · ClinicalTrials.gov registry record · Phase 1
Protective Effect of Nicotinamide Riboside Against Acetaminophen Toxicity
A Phase 1 study, sponsored by University of South Alabama.
- Completed
- Registry status
- Phase 1
- Development phase
- 26
- Enrollment target
NCT06214468: Completed Phase 1 study, sponsored by University of South Alabama.
NCT06214468 is a Phase 1 study that has completed, run by University of South Alabama. The registered enrollment target is 26 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (57% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06214468, a Phase 1 study, has completed, sponsored by University of South Alabama.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 26 participants
- Enrollment target
Study Summary
Over-the-counter drugs like acetaminophen (e.g., Tylenol®) can be detrimental. In space, astronauts who have pain and constant discomfort use acetaminophen extensively. Investigators are studying the effects of acetaminophen under space-like conditions since acetaminophen might affect astronauts' health. Investigators also wish to see whether a dietary supplement can reduce some negative effects of acetaminophen. It is believed that acetaminophen promotes the productions of chemicals in the body that could be toxic. In this study, measurements of these chemicals in urine after ingestion of 1 tablet of acetaminophen and compare these measurements to when acetaminophen is taken at the same time as a dietary supplement. This study will also explore whether these products are more abundant when blood is placed under conditions that mimic space. Therefore, this study will collect blood from a few volunteers who took acetaminophen, and acetaminophen with the dietary supplement.
Primary Outcome
Multiple blood draws pre and post dose of acetaminophen plus NR
Interventions
- DRUG Acetaminophen
- COMBINATION_PRODUCT Acetaminophen and Nicotinamide Riboside
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 26 participants |
| Start Date | 2024-01-15 |
| Est. Completion | 2025-06-01 |
| Phase | Phase 1 |
What the finished NCT06214468 record still lists
NCT06214468 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 26 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (57% lower).
The record links to 0 conditions, and to 2 interventions - of which Acetaminophen is the first listed.
NCT06214468 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06214468 about?
NCT06214468 is a clinical study titled "Protective Effect of Nicotinamide Riboside Against Acetaminophen Toxicity". Over-the-counter drugs like acetaminophen (e.g., Tylenol®) can be detrimental. In space, astronauts who have pain and constant discomfort use acetaminophen extensively. Investigators are studying the effects of acetaminophen under space-like conditions since acetaminophen might affect astronauts' he...
What is the current status of trial NCT06214468?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 26 participants. The study started on 2024-01-15. Estimated completion is 2025-06-01.
What interventions are being tested in trial NCT06214468?
The interventions under investigation include: Acetaminophen (DRUG), Acetaminophen and Nicotinamide Riboside (COMBINATION_PRODUCT).
Who is sponsoring clinical trial NCT06214468?
This trial is sponsored by University of South Alabama, which has 17 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06214468's enrollment target sits among peer trials
26 1482nd of 2000 higher than 506 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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