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NCT06185179 · ClinicalTrials.gov registry record · Early Phase 1
Metformin and Muscle Recovery
A Early Phase 1 study of Muscle Atrophy or Weakness, sponsored by University of Utah.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT06185179 is a Early Phase 1 study of Muscle Atrophy or Weakness that is actively recruiting participants, run by University of Utah. The registered enrollment target is 50 participants. The trial reports 1 study location across 1 state.
The verdict
NCT06185179, a Early Phase 1 study of Muscle Atrophy or Weakness, is actively recruiting participants, sponsored by University of Utah.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
A hallmark of aging is an impaired ability to adequately recover following a stressor, such as muscle disuse, resulting in muscle fibrosis and weakness thereby increasing the risk for falls and loss of independence. Mechanistic-based therapeutic strategies to enhance muscle recovery in older adults do not exist. Metformin has been implicated to have positive effects on muscle size and function through non-glycemic mechanisms. Metformin has been shown to enhance macrophage function and lessen cellular senescence burden by targeting SASP in a variety of muscle interstitial cells. However, the role of metformin to improve muscle recovery in older adults following disuse atrophy through immunomodulating and senomorphic mechanisms have not been examined. Therefore, the purpose of this study is to conduct a randomized, double blind, placebo-controlled clinical trial in older adult participants to determine if short-term metformin delivery (vs placebo) during the recovery phase following disuse atrophy can improve muscle regrowth.
Conditions Studied
Interventions
- OTHER Placebo
- DRUG Metformin
Study Locations (1)
Utah
- University of Utah - Salt Lake City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2024-09-01 |
| Est. Completion | 2030-05-31 |
| Phase | Early Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06185179
The ClinicalTrials.gov registry entry for NCT06185179 describes a study currently listed as recruiting, categorized as Early Phase 1. The registered enrollment target is 50 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Utah, which has 818 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Muscle Atrophy or Weakness appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT06185179 reports 1 study location spanning 1 distinct geographic area - top geographies include Utah.
Frequently Asked Questions
What is clinical trial NCT06185179 about?
NCT06185179 is a clinical study titled "Metformin and Muscle Recovery". A hallmark of aging is an impaired ability to adequately recover following a stressor, such as muscle disuse, resulting in muscle fibrosis and weakness thereby increasing the risk for falls and loss of independence. Mechanistic-based therapeutic strategies to enhance muscle recovery in older adults ...
What is the current status of trial NCT06185179?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 50 participants. The study started on 2024-09-01. Estimated completion is 2030-05-31.
What conditions does trial NCT06185179 study?
This clinical trial studies the following conditions: Muscle Atrophy or Weakness.
What interventions are being tested in trial NCT06185179?
The interventions under investigation include: Placebo (OTHER), Metformin (DRUG).
Who is sponsoring clinical trial NCT06185179?
This trial is sponsored by University of Utah, which has 818 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06185179 being conducted?
This trial has 1 study location across Utah. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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