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NCT06140927 · ClinicalTrials.gov registry record · Phase 3

Effect of Ketamine on Intraoperative Motor Evoked Potentials

A Phase 3 study of Spinal Stenosis and Spine Fusion, sponsored by University of California, San Francisco.

Recruiting
Registry status
Phase 3
Development phase
20
Enrollment target
1
Study location

NCT06140927: Recruiting Phase 3 study of Spinal Stenosis and Spine Fusion, sponsored by University of California, San Francisco.

NCT06140927 is a Phase 3 study of Spinal Stenosis and Spine Fusion that is actively recruiting participants, run by University of California, San Francisco. The registered enrollment target is 20 participants, below the 549-participant average among 15 other Spinal Stenosis trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT06140927, a Phase 3 study of Spinal Stenosis and Spine Fusion, is actively recruiting participants, sponsored by University of California, San Francisco.

RECRUITING
Registry status
Phase 3
Development phase
20 participants
Enrollment target
1
Study location

Study Summary

The goal of this clinical trial is to learn about the effect of ketamine on intraoperative motor evoked potentials in adult patients undergoing thoracolumbar spinal fusions. Participants will undergo a standard anesthetic. In addition to the standard anesthetic, the patients will be administered increasing doses of ketamine with motor-evoked potentials being measured at each dose, to assess any impacts.

Primary Outcome

MEP helps to monitor the integrity and function of the spinal cord and alert the surgeon of any potential injury during the spine surgery. MEP amplitude will be measured at each of 3 ketamine doses and compared to baseline. The measurements will be at each dose change of ketamine approximately 10, 20 and 30 minutes after the start of the ketamine infusions.

Conditions Studied

Spinal Stenosis Spine Fusion Spine Tumor

Interventions

  • DRUG Ketamine

Study Locations (1)

California

  • University of California, San Francisco - San Francisco

Trial Details

FieldValue
Enrollment Target 20 participants
Start Date 2023-12-01
Est. Completion 2026-12-01
Phase Phase 3
University of California, San Francisco

1,713 total trials

What NCT06140927 shows while recruiting

NCT06140927 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 549-participant average among 15 other Spinal Stenosis trials with a reported enrollment target (96% lower).

The record links to 3 conditions, with Spinal Stenosis appearing as the primary indexed condition, and to 1 intervention - of which Ketamine is the first listed.

NCT06140927 reports a single indexed study location in California.

Frequently Asked Questions

What is clinical trial NCT06140927 about?

NCT06140927 is a clinical study titled "Effect of Ketamine on Intraoperative Motor Evoked Potentials". The goal of this clinical trial is to learn about the effect of ketamine on intraoperative motor evoked potentials in adult patients undergoing thoracolumbar spinal fusions. Participants will undergo a standard anesthetic. In addition to the standard anesthetic, the patients will be administered inc...

What is the current status of trial NCT06140927?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 20 participants. The study started on 2023-12-01. Estimated completion is 2026-12-01.

What conditions does trial NCT06140927 study?

This clinical trial studies the following conditions: Spinal Stenosis, Spine Fusion, Spine Tumor.

What interventions are being tested in trial NCT06140927?

The interventions under investigation include: Ketamine (DRUG).

Who is sponsoring clinical trial NCT06140927?

This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06140927 being conducted?

This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Spinal Stenosis

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT06140927's enrollment target sits among peer trials

20 16th of 15 the lowest of 15 other Spinal Stenosis trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Spinal Stenosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT06140927

Source: ClinicalTrials.gov NCT06140927, the US trial registry maintained by the National Library of Medicine. NCT06140927 (small enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.