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NCT06135051 · ClinicalTrials.gov registry record · Phase 1
Ultrasonic Neuromodulation for Treatment of Cognitive Impairment
A Phase 1 study, sponsored by University of Utah.
- Terminated
- Registry status
- Phase 1
- Development phase
- 1
- Enrollment target
NCT06135051: Clinical Trial Phase 1 study, sponsored by University of Utah.
NCT06135051 is a Phase 1 study that was terminated before completion, run by University of Utah. The registered enrollment target is 1 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06135051, a Phase 1 study, was terminated before completion, sponsored by University of Utah.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 1 participants
- Enrollment target
Study Summary
This study will evaluate a new form of non-invasive deep brain therapy for individuals with Alzheimer's disease. Low-intensity transcranial focused ultrasound stimulation will first be delivered using a range of stimulation parameters during psychophysical and physiological monitoring. A well-tolerated stimulation protocol will be selected for subsequent testing in a blinded randomized sham-controlled cross-over trial. The trial will evaluate brain target engagement using magnetic resonance imaging, PET imaging, and numerical scales of cognitive performance.
Primary Outcome
The MoCA is a 30-point test to detect cognitive impairment. Scores range from 0 (poor) and 30 (perfect).
Interventions
- DEVICE Diadem prototype
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1 participants |
| Start Date | 2024-08-18 |
| Est. Completion | 2024-08-21 |
| Phase | Phase 1 |
Why NCT06135051 stopped before completion
NCT06135051 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 1 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 1 intervention - of which Diadem prototype is the first listed.
NCT06135051 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06135051 about?
NCT06135051 is a clinical study titled "Ultrasonic Neuromodulation for Treatment of Cognitive Impairment". This study will evaluate a new form of non-invasive deep brain therapy for individuals with Alzheimer's disease. Low-intensity transcranial focused ultrasound stimulation will first be delivered using a range of stimulation parameters during psychophysical and physiological monitoring. A well-tolera...
What is the current status of trial NCT06135051?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 1 participants. The study started on 2024-08-18. Estimated completion is 2024-08-21.
What interventions are being tested in trial NCT06135051?
The interventions under investigation include: Diadem prototype (DEVICE).
Who is sponsoring clinical trial NCT06135051?
This trial is sponsored by University of Utah, which has 818 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06135051's enrollment target sits among peer trials
1 2001st of 2000 the lowest of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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