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NCT06129604 · ClinicalTrials.gov registry record · Phase 2
Pilot Window of Opportunity Trial (POET)
A Phase 2 study of Endometrial Carcinoma (EC) and Colorectal Carcinoma (CRC), sponsored by University of Oklahoma.
- Active
- Registry status
- Phase 2
- Development phase
- 10
- Enrollment target
- 1
- Study location
NCT06129604: Active Phase 2 study of Endometrial Carcinoma (EC) and Colorectal Carcinoma (CRC), sponsored by University of Oklahoma.
NCT06129604 is a Phase 2 study of Endometrial Carcinoma (EC) and Colorectal Carcinoma (CRC) that is active but no longer recruiting, run by University of Oklahoma. The registered enrollment target is 10 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06129604, a Phase 2 study of Endometrial Carcinoma (EC) and Colorectal Carcinoma (CRC), is active but no longer recruiting, sponsored by University of Oklahoma.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
The proposed clinical trial with TPST-1495 can help people with two types of cancer, Endometrial Cancer (EC) and Colorectal Carcinoma (CRC), who need surgery. The investigator plans to evaluate how well TPST-1495 works against these cancers by checking blood samples and tumor tissues taken before and after the treatment to see if it is an effective treatment option to help the immune system fight against cancer.
Primary Outcome
Blood samples from patients with EC and/or CRC will be assessed at screening(pre-dose) and post-surgery to evaluate the expression of EP2 and EP4 receptor biomarkers within the PGE2 signaling pathway, providing insights into impact of TPST-1495 on pharmacodynamic pathway changes.
Conditions Studied
Interventions
- DRUG TPST-1495
Study Locations (1)
Oklahoma
- OU Health Stephenson Cancer Center - Oklahoma City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2024-04-03 |
| Est. Completion | 2026-06-30 |
| Phase | Phase 2 |
What the registry record for NCT06129604 still lists
NCT06129604 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (92% lower).
The record links to 2 conditions, with Endometrial Carcinoma (EC) appearing as the primary indexed condition, and to 1 intervention - of which TPST-1495 is the first listed.
NCT06129604 reports a single indexed study location in Oklahoma.
Frequently Asked Questions
What is clinical trial NCT06129604 about?
NCT06129604 is a clinical study titled "Pilot Window of Opportunity Trial (POET)". The proposed clinical trial with TPST-1495 can help people with two types of cancer, Endometrial Cancer (EC) and Colorectal Carcinoma (CRC), who need surgery. The investigator plans to evaluate how well TPST-1495 works against these cancers by checking blood samples and tumor tissues taken before an...
What is the current status of trial NCT06129604?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 10 participants. The study started on 2024-04-03. Estimated completion is 2026-06-30.
What conditions does trial NCT06129604 study?
This clinical trial studies the following conditions: Endometrial Carcinoma (EC), Colorectal Carcinoma (CRC).
What interventions are being tested in trial NCT06129604?
The interventions under investigation include: TPST-1495 (DRUG).
Who is sponsoring clinical trial NCT06129604?
This trial is sponsored by University of Oklahoma, which has 358 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06129604 being conducted?
This trial has 1 study location across Oklahoma. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Endometrial Carcinoma (EC)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06129604's enrollment target sits among peer trials
10 1968th of 2000 higher than 12 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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