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NCT06119854 · ClinicalTrials.gov registry record · NA
Brief Digital Intervention to Increase COVID-19 Vaccination Among Individuals With Anxiety or Depression
A NA study, sponsored by City University of New York, School of Public Health.
- Completed
- Registry status
- NA
- Development phase
- 1,419
- Enrollment target
NCT06119854: Completed NA study, sponsored by City University of New York, School of Public Health.
NCT06119854 is a NA study that has completed, run by City University of New York, School of Public Health. The registered enrollment target is 1,419 participants, roughly in line with the 1,404-participant average among 58,714 other NA trials with a reported enrollment target. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06119854, a NA study, has completed, sponsored by City University of New York, School of Public Health.
- COMPLETED
- Registry status
- NA
- Development phase
- 1,419 participants
- Enrollment target
Study Summary
The COVID-19 pandemic has led to a mis/disinformation ecosystem that promotes divergent views of vaccine efficacy, as well as the legitimacy of science and medicine. Individuals are confronted with vaccine-related information from a multitude of sources, posing a challenge to identifying inaccurate information. COVID-19 vaccine uptake is lower among people with anxiety and depression than in the general population, due in part to higher levels of vaccine hesitancy. The prevalence of anxiety and depressive symptoms among US adults increased significantly during the COVID pandemic and has remained elevated. Interventions capable of mitigating the impact of vaccine hesitancy and mis/disinformation among undervaccinated people with anxiety or depression are therefore an urgent priority. Emerging evidence suggests that reasons for vaccine hesitancy and the impact of conventional vaccination messaging differ between those with and without mental health symptoms. There may also be added challenges overcoming logistical barriers to vaccination for people with anxiety or depressive symptoms. The investigators aim to determine the effectiveness of two different brief digital intervention strategies compared with conventional public health messaging for increasing vaccine uptake in undervaccinated adults with and without anxiety or depressive symptoms. Attitudinal inoculation is a brief, scalable strategy that leverages the power of narrative, values, and emotion to strengthen resistance to mis/disinformation and reduce hesitancy. Though this approach has been shown to decrease COVID-19 vaccine hesitancy among US adults, the extent to which this approach increases COVID-19 vaccination remains unknown. Cognitive-behavioral therapy (CBT) is an evidence-based intervention for anxiety and depression. However, the efficacy of incorporating CBT-informed messaging in a vaccine promotion intervention has not been tested. The investigators hypothesize that both attitudinal inoculation
Primary Outcome
Following our theoretical premise that our intervention will impact the uptake of COVID-19 vaccination, the investigators define our primary outcome as self-reported receipt of a COVID vaccine dose in the 4 weeks post-intervention. Risk ratios will be used to estimate and compare the proportion of participants in each arm who achieved the outcome. The investigators will adjust for differences in measured pre-baseline variables to address potential imbalances and conduct a mediation analysis to b
Interventions
- BEHAVIORAL Attitudinal inoculation
- BEHAVIORAL Cognitive-behavioral therapy-informed intervention
- BEHAVIORAL Conventional public health messaging
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,419 participants |
| Start Date | 2024-04-15 |
| Est. Completion | 2024-11-15 |
| Phase | NA |
What the finished NCT06119854 record still lists
NCT06119854 is an interventional study that assigns participants to a tested intervention. Its 1,419 participants enrollment target places it among the larger protocols in the corpus, roughly in line with the 1,404-participant average among 58,714 other NA trials with a reported enrollment target.
The record links to 0 conditions, and to 3 interventions - of which Attitudinal inoculation is the first listed.
NCT06119854 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06119854 about?
NCT06119854 is a clinical study titled "Brief Digital Intervention to Increase COVID-19 Vaccination Among Individuals With Anxiety or Depression". The COVID-19 pandemic has led to a mis/disinformation ecosystem that promotes divergent views of vaccine efficacy, as well as the legitimacy of science and medicine. Individuals are confronted with vaccine-related information from a multitude of sources, posing a challenge to identifying inaccurate ...
What is the current status of trial NCT06119854?
This trial is currently completed. It is a NA study. The enrollment target is 1,419 participants. The study started on 2024-04-15. Estimated completion is 2024-11-15.
What interventions are being tested in trial NCT06119854?
The interventions under investigation include: Attitudinal inoculation (BEHAVIORAL), Cognitive-behavioral therapy-informed intervention (BEHAVIORAL), Conventional public health messaging (BEHAVIORAL).
Who is sponsoring clinical trial NCT06119854?
This trial is sponsored by City University of New York, School of Public Health, which has 10 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06119854's enrollment target sits among peer trials
1,419 70th of 2000 higher than 1,931 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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