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NCT06118567 · ClinicalTrials.gov registry record · Phase 2
Effect of Nitrous Oxide on Aggression.
A Phase 2 study of Intermittent Explosive Disorder, sponsored by Ohio State University.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT06118567 is a Phase 2 study of Intermittent Explosive Disorder that is actively recruiting participants, run by Ohio State University. The registered enrollment target is 50 participants, below the 90-participant average among 3 other Intermittent Explosive Disorder trials with a reported enrollment target (44% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06118567, a Phase 2 study of Intermittent Explosive Disorder, is actively recruiting participants, sponsored by Ohio State University.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this experimental medicine clinical trial is to test the hypothesis that nitrous oxide inhalation will result in a change in neurocircuit function in healthy controls and in individuals with impulsive aggressive tendencies. The main question aims to answer are: Does Nitrous Oxide normalize brain circuit function in impulsively aggressive individuals 24 hours after inhalation. Participants will undergo a 60 minute inhalation session with 50% Nitrous Oxide (or room air at another session) and then undergo an fMRI scan 24 hours later. Researchers will compare healthy controls and impulsively aggressive individuals to see if Nitrous Oxide can normalize the function of cortico-limbic circuits in the latter group.
Conditions Studied
Interventions
- DRUG Nitrous oxide
- DRUG Room Air
Study Locations (1)
Ohio
- Ohio State University Wexner Medical Center - Columbus
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2022-09-06 |
| Est. Completion | 2027-08-31 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06118567
The ClinicalTrials.gov registry entry for NCT06118567 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 50 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 90-participant average among 3 other Intermittent Explosive Disorder trials with a reported enrollment target (44% lower). The listed sponsor is Ohio State University, which has 552 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Intermittent Explosive Disorder appearing as the primary indexed condition, and to 2 interventions - of which Nitrous oxide is the first listed.
NCT06118567 reports 1 study location spanning 1 distinct geographic area - top geographies include Ohio.
Frequently Asked Questions
What is clinical trial NCT06118567 about?
NCT06118567 is a clinical study titled "Effect of Nitrous Oxide on Aggression.". The goal of this experimental medicine clinical trial is to test the hypothesis that nitrous oxide inhalation will result in a change in neurocircuit function in healthy controls and in individuals with impulsive aggressive tendencies. The main question aims to answer are: Does Nitrous Oxide normali...
What is the current status of trial NCT06118567?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 50 participants. The study started on 2022-09-06. Estimated completion is 2027-08-31.
What conditions does trial NCT06118567 study?
This clinical trial studies the following conditions: Intermittent Explosive Disorder.
What interventions are being tested in trial NCT06118567?
The interventions under investigation include: Nitrous oxide (DRUG), Room Air (DRUG).
Who is sponsoring clinical trial NCT06118567?
This trial is sponsored by Ohio State University, which has 552 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06118567 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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