Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 2

A Clinical Trial to Evaluate Efficacy and Safety of TransCon CNP Compared With Placebo in Infants (0 to <2 Years of Age) With Achondroplasia

NCT06079398 · View on ClinicalTrials.gov ↗

Study Summary

This trial is a Phase 2, multicenter, double-blind, randomized (ratio 2:1 TransCon CNP vs. placebo), placebo-controlled trial, designed to evaluate the safety, tolerability, and efficacy of 100 μg CNP/kg of Navepegritide (TransCon CNP) administered SC once-weekly for 52 weeks in infants with genetically verified heterozygous ACH, aged 0 to \< 2 years at the time of randomization.

Conditions Studied

Interventions

  • DRUG Navepegritide
  • DRUG Placebo for Navepegritide

Study Locations (17)

Other

  • Ascendis Investigational Site — Parkville
  • Ascendis Investigational Site — Linz
  • Ascendis Investigational Site — Copenhagen
  • Ascendis Investigational Site — Helsinki
  • Ascendis Investigational Site — Paris
  • Ascendis Investigational Site — Berlin
  • Ascendis Investigational Site — Cologne
  • Ascendis Investigational Site — Dublin
  • Ascendis Investigational Site — Milan
  • Ascendis Investigational Site — Auckland
  • Ascendis Investigational Site — Oslo
  • Ascendis Investigational Site — Coimbra
  • Ascendis Investigational Site — Stockholm
  • Ascendis Investigational Site — London

Minnesota

  • Ascendis Investigational Site — Saint Paul

Texas

  • Ascendis Investigational Site — Houston

Wisconsin

  • Ascendis Investigational Site — Madison

Trial Details

FieldValue
Enrollment Target 72 participants
Start Date 2024-01-23
Est. Completion 2028-12
Phase Phase 2

Sponsor

Ascendis Pharma A/S

34 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06079398

The ClinicalTrials.gov registry entry for NCT06079398 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 72 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Ascendis Pharma A/S, which has 34 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Achondroplasia appearing as the primary indexed condition, and to 2 interventions — of which Navepegritide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06079398 reports 17 study locations spanning 4 distinct geographic areas — top geographies include Other, Minnesota, Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06079398 about?

NCT06079398 is a clinical study titled "A Clinical Trial to Evaluate Efficacy and Safety of TransCon CNP Compared With Placebo in Infants (0 to <2 Years of Age) With Achondroplasia". This trial is a Phase 2, multicenter, double-blind, randomized (ratio 2:1 TransCon CNP vs. placebo), placebo-controlled trial, designed to evaluate the safety, tolerability, and efficacy of 100 μg CNP/kg of Navepegritide (TransCon CNP) administered SC once-weekly for 52 weeks in infants with genetic...

What is the current status of trial NCT06079398?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 72 participants. The study started on 2024-01-23. Estimated completion is 2028-12.

What conditions does trial NCT06079398 study?

This clinical trial studies the following conditions: Achondroplasia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06079398?

The interventions under investigation include: Navepegritide (DRUG), Placebo for Navepegritide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06079398?

This trial is sponsored by Ascendis Pharma A/S, which has 34 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06079398 being conducted?

This trial has 17 study locations across Minnesota, Texas, Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial