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ACTIVE NOT RECRUITING Phase 2

A Platform Study of Novel Immunotherapy Combinations as First-Line Treatment in Participants With PD-L1 Positive Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck- GALAXIES H&N-202

NCT06062420 · View on ClinicalTrials.gov ↗

Study Summary

The primary purpose of the study is to evaluate the antitumor activity and safety of novel immunotherapy combinations compared with dostarlimab in participants with Programmed death ligand 1 (PD-L1) positive Recurrent/Metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC).

Conditions Studied

Interventions

  • DRUG Dostarlimab
  • DRUG Remzistotug
  • DRUG Belrestotug
  • DRUG Nelistotug

Study Locations (20)

Other

  • GSK Investigational Site — Buenos Aires
  • GSK Investigational Site — Capital Federal
  • GSK Investigational Site — Ciudad Autonoma de Bueno
  • GSK Investigational Site — Córdoba
  • GSK Investigational Site — Florida
  • GSK Investigational Site — Mendoza
  • GSK Investigational Site — San Juan
  • GSK Investigational Site — Santa Fe
  • GSK Investigational Site — Santo André
  • GSK Investigational Site — São Paulo
  • GSK Investigational Site — São Paulo

Alberta

  • GSK Investigational Site — Calgary
  • GSK Investigational Site — Edmonton

Ontario

  • GSK Investigational Site — Toronto
  • GSK Investigational Site — Toronto

Connecticut

  • GSK Investigational Site — New Haven

Iowa

  • GSK Investigational Site — Iowa City

Missouri

  • GSK Investigational Site — St Louis

Ohio

  • GSK Investigational Site — Columbus

Wisconsin

  • GSK Investigational Site — Milwaukee

Trial Details

FieldValue
Enrollment Target 316 participants
Start Date 2023-11-14
Est. Completion 2027-07-22
Phase Phase 2

Sponsor

GlaxoSmithKline

558 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06062420

The ClinicalTrials.gov registry entry for NCT06062420 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 316 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is GlaxoSmithKline, which has 558 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Neoplasms, Head and Neck appearing as the primary indexed condition, and to 4 interventions — of which Dostarlimab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06062420 reports 20 study locations spanning 8 distinct geographic areas — top geographies include Other, Alberta, Ontario. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06062420 about?

NCT06062420 is a clinical study titled "A Platform Study of Novel Immunotherapy Combinations as First-Line Treatment in Participants With PD-L1 Positive Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck- GALAXIES H&N-202". The primary purpose of the study is to evaluate the antitumor activity and safety of novel immunotherapy combinations compared with dostarlimab in participants with Programmed death ligand 1 (PD-L1) positive Recurrent/Metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC).

What is the current status of trial NCT06062420?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 316 participants. The study started on 2023-11-14. Estimated completion is 2027-07-22.

What conditions does trial NCT06062420 study?

This clinical trial studies the following conditions: Neoplasms, Head and Neck. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06062420?

The interventions under investigation include: Dostarlimab (DRUG), Remzistotug (DRUG), Belrestotug (DRUG), Nelistotug (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06062420?

This trial is sponsored by GlaxoSmithKline, which has 558 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06062420 being conducted?

This trial has 20 study locations across Connecticut, Iowa, Missouri, Ohio, Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial