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NCT06050707 · ClinicalTrials.gov registry record · Phase 2
MR-Adaptive Radiation Therapy for Anal Cancer With EScalated-Treatment in a Risk-Optimized Approach
A Phase 2 study of Anal Squamous Cell Carcinoma, sponsored by University Health Network, Toronto.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 80
- Enrollment target
- 4
- Study locations
NCT06050707: Recruiting Phase 2 study of Anal Squamous Cell Carcinoma, sponsored by University Health Network, Toronto.
NCT06050707 is a Phase 2 study of Anal Squamous Cell Carcinoma that is actively recruiting participants, run by University Health Network, Toronto. The registered enrollment target is 80 participants, roughly in line with the 77-participant average among 5 other Anal Squamous Cell Carcinoma trials with a reported enrollment target. The trial reports 4 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06050707, a Phase 2 study of Anal Squamous Cell Carcinoma, is actively recruiting participants, sponsored by University Health Network, Toronto.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 80 participants
- Enrollment target
- 4
- Study locations
Study Summary
The proposed study is a phase II, single arm, open-label trial of MR-guided radiation therapy (RT) with risk stratified RT dose selection in patients with anal cancer. Based on previous data, a risk adaptive treatment approached is proposed in 4 groups: Low risk, standard risk, intermediate risk, and high risk. Human papillomavirus (HPV) DNA will be analyzed to identify novel biomarkers that predict chemoradiotherapy (CRT) response and toxicity.
Primary Outcome
Any local or regional failure from the date of registration to the date of any of the local or regional failure.
Conditions Studied
Interventions
- RADIATION Radiotherapy - Low risk group
- RADIATION Radiotherapy - Standard risk group
- RADIATION Radiotherapy - Intermediate risk group
- RADIATION Radiotherapy - High risk group
Study Locations (4)
Pennsylvania
- Allegheny Health Network - Pittsburgh
Wisconsin
- Medical College of Wisconsin Cancer Center - Milwaukee
Victoria
- Austin Health - Heidelberg
Ontario
- Princess Margaret Cancer Centre - Toronto
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2023-09-29 |
| Est. Completion | 2028-09-01 |
| Phase | Phase 2 |
What NCT06050707 shows while recruiting
NCT06050707 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, roughly in line with the 77-participant average among 5 other Anal Squamous Cell Carcinoma trials with a reported enrollment target.
The record links to 1 condition, with Anal Squamous Cell Carcinoma appearing as the primary indexed condition, and to 4 interventions - of which Radiotherapy - Low risk group is the first listed.
NCT06050707 reports a single indexed study location in Pennsylvania, Wisconsin, Victoria.
Frequently Asked Questions
What is clinical trial NCT06050707 about?
NCT06050707 is a clinical study titled "MR-Adaptive Radiation Therapy for Anal Cancer With EScalated-Treatment in a Risk-Optimized Approach". The proposed study is a phase II, single arm, open-label trial of MR-guided radiation therapy (RT) with risk stratified RT dose selection in patients with anal cancer. Based on previous data, a risk adaptive treatment approached is proposed in 4 groups: Low risk, standard risk, intermediate risk, an...
What is the current status of trial NCT06050707?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 80 participants. The study started on 2023-09-29. Estimated completion is 2028-09-01.
What conditions does trial NCT06050707 study?
This clinical trial studies the following conditions: Anal Squamous Cell Carcinoma.
What interventions are being tested in trial NCT06050707?
The interventions under investigation include: Radiotherapy - Low risk group (RADIATION), Radiotherapy - Standard risk group (RADIATION), Radiotherapy - Intermediate risk group (RADIATION), Radiotherapy - High risk group (RADIATION).
Who is sponsoring clinical trial NCT06050707?
This trial is sponsored by University Health Network, Toronto, which has 23 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06050707 being conducted?
This trial has 4 study locations across Pennsylvania, Wisconsin, Victoria, Ontario. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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