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RECRUITING Phase 2

MR-Adaptive Radiation Therapy for Anal Cancer With EScalated-Treatment in a Risk-Optimized Approach

NCT06050707 · View on ClinicalTrials.gov ↗

Study Summary

The proposed study is a phase II, single arm, open-label trial of MR-guided radiation therapy (RT) with risk stratified RT dose selection in patients with anal cancer. Based on previous data, a risk adaptive treatment approached is proposed in 4 groups: Low risk, standard risk, intermediate risk, and high risk. Human papillomavirus (HPV) DNA will be analyzed to identify novel biomarkers that predict chemoradiotherapy (CRT) response and toxicity.

Interventions

  • RADIATION Radiotherapy - Low risk group
  • RADIATION Radiotherapy - Standard risk group
  • RADIATION Radiotherapy - Intermediate risk group
  • RADIATION Radiotherapy - High risk group

Study Locations (4)

Pennsylvania

  • Allegheny Health Network — Pittsburgh

Wisconsin

  • Medical College of Wisconsin Cancer Center — Milwaukee

Victoria

  • Austin Health — Heidelberg

Ontario

  • Princess Margaret Cancer Centre — Toronto

Trial Details

FieldValue
Enrollment Target 80 participants
Start Date 2023-09-29
Est. Completion 2028-09-01
Phase Phase 2

Sponsor

University Health Network, Toronto

67 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06050707

The ClinicalTrials.gov registry entry for NCT06050707 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University Health Network, Toronto, which has 67 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Anal Squamous Cell Carcinoma appearing as the primary indexed condition, and to 4 interventions — of which Radiotherapy - Low risk group is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06050707 reports 4 study locations spanning 4 distinct geographic areas — top geographies include Pennsylvania, Wisconsin, Victoria. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06050707 about?

NCT06050707 is a clinical study titled "MR-Adaptive Radiation Therapy for Anal Cancer With EScalated-Treatment in a Risk-Optimized Approach". The proposed study is a phase II, single arm, open-label trial of MR-guided radiation therapy (RT) with risk stratified RT dose selection in patients with anal cancer. Based on previous data, a risk adaptive treatment approached is proposed in 4 groups: Low risk, standard risk, intermediate risk, an...

What is the current status of trial NCT06050707?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 80 participants. The study started on 2023-09-29. Estimated completion is 2028-09-01.

What conditions does trial NCT06050707 study?

This clinical trial studies the following conditions: Anal Squamous Cell Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06050707?

The interventions under investigation include: Radiotherapy - Low risk group (RADIATION), Radiotherapy - Standard risk group (RADIATION), Radiotherapy - Intermediate risk group (RADIATION), Radiotherapy - High risk group (RADIATION). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06050707?

This trial is sponsored by University Health Network, Toronto, which has 67 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06050707 being conducted?

This trial has 4 study locations across Pennsylvania, Wisconsin, Victoria, Ontario. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial