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NCT06046820 · ClinicalTrials.gov registry record · Phase 3
The ENERGY 3 Study: Evaluation of Efficacy and Safety of INZ-701 in Children With ENPP1 Deficiency
A Phase 3 study of Ectonucleotide Pyrophosphatase/phosphodiesterase1 Deficiency and Autosomal Recessive Hypophosphatemic Rickets, sponsored by Inozyme Pharma.
- Active
- Registry status
- Phase 3
- Development phase
- 27
- Enrollment target
- 15
- Study locations
NCT06046820: Active Phase 3 study of Ectonucleotide Pyrophosphatase/phosphodiesterase1 Deficiency and Autosomal Recessive Hypophosphatemic Rickets, sponsored by Inozyme Pharma.
NCT06046820 is a Phase 3 study of Ectonucleotide Pyrophosphatase/phosphodiesterase1 Deficiency and Autosomal Recessive Hypophosphatemic Rickets that is active but no longer recruiting, run by Inozyme Pharma. The registered enrollment target is 27 participants, below the 306-participant average among 4 other Ectonucleotide Pyrophosphatase/phosphodiesterase1 Deficiency trials with a reported enrollment target (91% lower). The trial reports 15 study locations across 7 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06046820, a Phase 3 study of Ectonucleotide Pyrophosphatase/phosphodiesterase1 Deficiency and Autosomal Recessive Hypophosphatemic Rickets, is active but no longer recruiting, sponsored by Inozyme Pharma.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 3
- Development phase
- 27 participants
- Enrollment target
- 15
- Study locations
Study Summary
The primary purpose of Study INZ701-106 (The ENERGY 3 Study) is to assess the efficacy and safety of INZ-701 in children with ENPP1 Deficiency.
Primary Outcome
For each subject, plasma PPi will be measured via a series of blood samples obtained throughout the study, comparing the subject's baseline value over time.
Conditions Studied
Interventions
- DRUG INZ-701
- DRUG Control Arm (Conventional Therapy)
Study Locations (15)
Other
- Queensland Children's Hospital - South Brisbane
- Centre Hospitalier Universitaire (CHU) Sainte-Justine - Montreal
- Hôpital Bicêtre, Service d'endocrinologie et diabète de l'enfant (Childhood Endocrinology and Diabetes Department) - Le Kremlin-Bicêtre
- King Faisal Specialist Hospital and Research Centre - Riyadh
- Hospital San Joan de Deu - Barcelona
- Umraniye Training and Research Hospital - Istanbul
- Cukurova Universitesi Tip Fakultesi - Sarıçam
- Al Jalila Children's Specialty Hospital - Dubai
- Royal Manchester Children's Hospital - Manchester
Colorado
- Children's Hospital of Colorado - Aurora
Illinois
- Ann & Robert H. Lurie Children's Hospital - Chicago
Massachusetts
- Boston Children's Hospital - Boston
Ohio
- Nationwide Children's Hospital - Columbus
Pennsylvania
- The Children's Hospital of Philadelphia - Philadelphia
Texas
- Cook Children's Medical Center - Fort Worth
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 27 participants |
| Start Date | 2023-11-05 |
| Est. Completion | 2026-02 |
| Phase | Phase 3 |
What the registry record for NCT06046820 still lists
NCT06046820 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 27 participants, a relatively small participant target, below the 306-participant average among 4 other Ectonucleotide Pyrophosphatase/phosphodiesterase1 Deficiency trials with a reported enrollment target (91% lower).
The record links to 3 conditions, with Ectonucleotide Pyrophosphatase/phosphodiesterase1 Deficiency appearing as the primary indexed condition, and to 2 interventions - of which INZ-701 is the first listed.
NCT06046820 lists 15 locations in 7 states (Other, Colorado, Illinois).
Frequently Asked Questions
What is clinical trial NCT06046820 about?
NCT06046820 is a clinical study titled "The ENERGY 3 Study: Evaluation of Efficacy and Safety of INZ-701 in Children With ENPP1 Deficiency". The primary purpose of Study INZ701-106 (The ENERGY 3 Study) is to assess the efficacy and safety of INZ-701 in children with ENPP1 Deficiency.
What is the current status of trial NCT06046820?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 27 participants. The study started on 2023-11-05. Estimated completion is 2026-02.
What conditions does trial NCT06046820 study?
This clinical trial studies the following conditions: Ectonucleotide Pyrophosphatase/phosphodiesterase1 Deficiency, Autosomal Recessive Hypophosphatemic Rickets, Generalized Arterial Calcification of Infancy.
What interventions are being tested in trial NCT06046820?
The interventions under investigation include: INZ-701 (DRUG), Control Arm (Conventional Therapy) (DRUG).
Who is sponsoring clinical trial NCT06046820?
This trial is sponsored by Inozyme Pharma, which has 9 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06046820 being conducted?
This trial has 15 study locations across Colorado, Illinois, Massachusetts, Ohio, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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