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NCT06043414 · ClinicalTrials.gov registry record · NA
Barbed Suture vs Non-Barbed Closure for Emergency Exploratory Laparotomy RCT
A NA study, sponsored by University of Southern California.
- Not yet
- Registry status
- NA
- Development phase
- 250
- Enrollment target
NCT06043414: Clinical Trial NA study, sponsored by University of Southern California.
NCT06043414 is a NA study that has not yet begun recruiting, run by University of Southern California. The registered enrollment target is 250 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (82% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06043414, a NA study, has not yet begun recruiting, sponsored by University of Southern California.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 250 participants
- Enrollment target
Study Summary
This randomized control trial aims to compare the efficacy of triclosan-coated barbed suture (TCB) versus conventional non-barbed polydioxanone (PDS) suture in the closure of the abdominal fascia after emergency exploratory laparotomy. The study addresses the common complications of incisional surgical site infections (SSI) and fascial dehiscence (FD) following emergency exploratory laparotomy. The primary objective is to assess the effectiveness of triclosan-coated barbed suture and conventional non-barbed suture in reducing the rates of incisional SSI and FD within 30 days postoperatively. The study population comprises adult patients undergoing emergent laparotomy for traumatic injuries or acute intraabdominal pathology. This prospective, single-blinded randomized control trial will be conducted at Los Angeles General Medical Center. Patients will be randomized to receive either triclosan-coated barbed suture or conventional non-barbed suture for abdominal fascial closure, with a standard closure technique employed. Patients will be followed up for 30 days postoperatively to monitor surgical site infections, fascial dehiscence, and other outcomes. Statistical analysis will be conducted to compare outcomes between the study arms, assessing the efficacy of triclosan-coated barbed suture in reducing the incidence of SSI and FD, along with secondary outcomes.
Primary Outcome
Composite incidence of superficial surgical site infections and abdominal fascial dehiscence
Interventions
- DEVICE triclosan-coated barbed suture
- DEVICE triclosan-coated non-barbed suture
- DEVICE Non-coated non-barbed suture
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 250 participants |
| Start Date | 2024-01-01 |
| Est. Completion | 2027-01-31 |
| Phase | NA |
What is known before NCT06043414 opens enrollment
NCT06043414 is an interventional study that assigns participants to a tested intervention. The registered 250 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (82% lower).
The record links to 0 conditions, and to 3 interventions - of which triclosan-coated barbed suture is the first listed.
NCT06043414 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06043414 about?
NCT06043414 is a clinical study titled "Barbed Suture vs Non-Barbed Closure for Emergency Exploratory Laparotomy RCT". This randomized control trial aims to compare the efficacy of triclosan-coated barbed suture (TCB) versus conventional non-barbed polydioxanone (PDS) suture in the closure of the abdominal fascia after emergency exploratory laparotomy. The study addresses the common complications of incisional surgi...
What is the current status of trial NCT06043414?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 250 participants. The study started on 2024-01-01. Estimated completion is 2027-01-31.
What interventions are being tested in trial NCT06043414?
The interventions under investigation include: triclosan-coated barbed suture (DEVICE), triclosan-coated non-barbed suture (DEVICE), Non-coated non-barbed suture (DEVICE).
Who is sponsoring clinical trial NCT06043414?
This trial is sponsored by University of Southern California, which has 617 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06043414's enrollment target sits among peer trials
250 410th of 2000 higher than 1,567 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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