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NCT06041048 · ClinicalTrials.gov registry record · Phase 4
Investigation of Locus Coeruleus Function in Sustained Attention
A Phase 4 study of Attention - no Condition is Being Assessed - Healthy Adults, sponsored by University of California, Davis.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT06041048: Recruiting Phase 4 study of Attention - no Condition is Being Assessed - Healthy Adults, sponsored by University of California, Davis.
NCT06041048 is a Phase 4 study of Attention - no Condition is Being Assessed - Healthy Adults that is actively recruiting participants, run by University of California, Davis. The registered enrollment target is 40 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06041048, a Phase 4 study of Attention - no Condition is Being Assessed - Healthy Adults, is actively recruiting participants, sponsored by University of California, Davis.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
The norepinephrine-producing locus coeruleus (LC) is thought to be central to a wide array of cognitive functions, like attention and goal pursuit, and has been implicated in dysfunctions including attention deficit hyperactivity disorder and schizophrenia. The goal of this proposal is to develop methods that permit measurement of activity in the human LC. Because the LC is small and located in the pons, the Investigators will use high resolution magnetic resonance imaging techniques tailored to the brainstem environment, including neuromelanin-sensitive images shown to delineate the LC, combined with pharmacological manipulation to confirm the location of functional activity.
Conditions Studied
Interventions
- DRUG Modafinil
Study Locations (1)
California
- University of California, Davis - Sacramento
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2023-10-01 |
| Est. Completion | 2025-12-30 |
| Phase | Phase 4 |
What NCT06041048 shows while recruiting
NCT06041048 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (92% lower).
The record links to 1 condition, with Attention - no Condition is Being Assessed - Healthy Adults appearing as the primary indexed condition, and to 1 intervention - of which Modafinil is the first listed.
NCT06041048 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT06041048 about?
NCT06041048 is a clinical study titled "Investigation of Locus Coeruleus Function in Sustained Attention". The norepinephrine-producing locus coeruleus (LC) is thought to be central to a wide array of cognitive functions, like attention and goal pursuit, and has been implicated in dysfunctions including attention deficit hyperactivity disorder and schizophrenia. The goal of this proposal is to develop me...
What is the current status of trial NCT06041048?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 40 participants. The study started on 2023-10-01. Estimated completion is 2025-12-30.
What conditions does trial NCT06041048 study?
This clinical trial studies the following conditions: Attention - no Condition is Being Assessed - Healthy Adults.
What interventions are being tested in trial NCT06041048?
The interventions under investigation include: Modafinil (DRUG).
Who is sponsoring clinical trial NCT06041048?
This trial is sponsored by University of California, Davis, which has 657 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06041048 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06041048's enrollment target sits among peer trials
40 1397th of 2000 higher than 534 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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