Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06021171 · ClinicalTrials.gov registry record · NA
Improving the Iron Status of Athletes With Pre-, Pro- and Synbiotics
A NA study of Iron Deficiency Anemia and Iron-deficiency, sponsored by King's College.
- Completed
- Registry status
- NA
- Development phase
- 10
- Enrollment target
- 1
- Study location
NCT06021171: Completed NA study of Iron Deficiency Anemia and Iron-deficiency, sponsored by King's College.
NCT06021171 is a NA study of Iron Deficiency Anemia and Iron-deficiency that has completed, run by King's College. The registered enrollment target is 10 participants, below the 193-participant average among 24 other Iron Deficiency Anemia trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06021171, a NA study of Iron Deficiency Anemia and Iron-deficiency, has completed, sponsored by King's College.
- COMPLETED
- Registry status
- NA
- Development phase
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
Iron deficiency (ID) is the most common micronutrient deficiency worldwide, and poor iron bioavailability is a major cause. While 30% of female athletes are affected by ID, and its consequences are highly relevant to athletic performance, ID affects women and children around the world with consequences just as relevant, if not more so (e.g. school performance, work capacity and thus wage earning). With poor iron absorption being a cause of ID in active women, it is especially important to discover simple ways to improve iron (Fe) uptake. While some studies have suggested that consumption of prebiotic fiber may improve Fe absorption in animal models, there have been few studies examining the effects of synbiotic supplementation (consumption of both a prebiotic and probiotic that work together) on Fe uptake in adult females (athletes and non-athletes). A recent pilot study demonstrated a substantial improvement in Fe uptake in female athletes after 4 and 8 weeks of synbiotic supplementation compared to placebo during Fe repletion with a low dose of ferrous sulfate (FeSO4). If synbiotic supplementation can improve the Fe bioavailability of FeSO4 (which is \~30%) in ID women during repletion of Fe status, it could possibly improve the Fe bioavailability of non-heme Fe sources, as well as mixed meals. Research Question: What is the effect of synbiotic supplementation (a supplement containing a prebiotic + a probiotic), compared to prebiotic supplementation or a placebo, on Fe uptake and the gut microbiome in ID athletes during low-dose Fe repletion? Hypothesis: In the proposed study, we hypothesize that synbiotic supplementation along with Fe repletion with a low dose of FeSO4 will have greatest impact on athletes' Fe uptake due to alterations in the microbiome, which will be assessed.
Primary Outcome
biomarker of iron status, iron stores, use to calculate Total body iron
Conditions Studied
Interventions
- DIETARY_SUPPLEMENT Maltodextrin
- DIETARY_SUPPLEMENT Partially hydrolyzed guar gum + bifidobacterium lactis
- DIETARY_SUPPLEMENT Partially hydrolyzed guar gum
Study Locations (1)
Pennsylvania
- King's College - Wilkes-Barre
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2021-08-15 |
| Est. Completion | 2022-05-15 |
| Phase | NA |
What the finished NCT06021171 record still lists
NCT06021171 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 193-participant average among 24 other Iron Deficiency Anemia trials with a reported enrollment target (95% lower).
The record links to 3 conditions, with Iron Deficiency Anemia appearing as the primary indexed condition, and to 3 interventions - of which Maltodextrin is the first listed.
NCT06021171 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT06021171 about?
NCT06021171 is a clinical study titled "Improving the Iron Status of Athletes With Pre-, Pro- and Synbiotics". Iron deficiency (ID) is the most common micronutrient deficiency worldwide, and poor iron bioavailability is a major cause. While 30% of female athletes are affected by ID, and its consequences are highly relevant to athletic performance, ID affects women and children around the world with consequen...
What is the current status of trial NCT06021171?
This trial is currently completed. It is a NA study. The enrollment target is 10 participants. The study started on 2021-08-15. Estimated completion is 2022-05-15.
What conditions does trial NCT06021171 study?
This clinical trial studies the following conditions: Iron Deficiency Anemia, Iron-deficiency, Iron Deficiency (Without Anemia).
What interventions are being tested in trial NCT06021171?
The interventions under investigation include: Maltodextrin (DIETARY_SUPPLEMENT), Partially hydrolyzed guar gum + bifidobacterium lactis (DIETARY_SUPPLEMENT), Partially hydrolyzed guar gum (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT06021171?
This trial is sponsored by King's College, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06021171 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Iron Deficiency Anemia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06021171's enrollment target sits among peer trials
10 23rd of 24 higher than 2 of 24 other Iron Deficiency Anemia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Iron Deficiency Anemia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Daily vs Alternate Day Iron Supplementation for Pregnant Women With Iron Deficiency Anemia
COMPLETED · NA
-
Effect of Iron Supplements on the Growth of Enteric Pathogens
COMPLETED · NA
-
Pilot Study of the Effect of Iron Fortified Rice in Iron Deficient Anemic Women
COMPLETED · NA
-
Total Dose Infusion of Ferumoxytol(1020mg) in 15 Minutes for Iron Deficiency Anemia
COMPLETED · NA
-
EHR-based Patient Identification and Panel Management of Patients With Iron Deficiency Anemia
COMPLETED · NA
-
Effects of Taking Prenatal Vitamin-mineral Supplements During Lactation on Iron Status and Markers of Oxidation
COMPLETED · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00623389 · 10 participants · NA
Evaluation of an Advanced Lower Extremity Neuroprostheses
- NCT01241864 · 10 participants · Phase 2
Islet Transplantation in Type 1 Diabetic Kidney Allograft
- NCT01293214 · 10 participants · NA
Vascularized Composite Allotransplantation for Multiple Extremity Amputations
- NCT01474148 · 10 participants · NA
A Neuroprosthesis for Seated Posture and Balance
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI