Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05987540 · ClinicalTrials.gov registry record · NA
SHARPEN - Parkinson's Disease Dementia
A NA study, sponsored by Scion NeuroStim.
- Terminated
- Registry status
- NA
- Development phase
- 9
- Enrollment target
NCT05987540: Clinical Trial NA study, sponsored by Scion NeuroStim.
NCT05987540 is a NA study that was terminated before completion, run by Scion NeuroStim. The registered enrollment target is 9 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05987540, a NA study, was terminated before completion, sponsored by Scion NeuroStim.
- TERMINATED
- Registry status
- NA
- Development phase
- 9 participants
- Enrollment target
Study Summary
The purpose of this single arm study is to evaluate the feasibility and safety of treatments with a non-invasive neuromodulation device in adults diagnosed with mild/moderate Parkinson's disease dementia (PDD). A non-invasive device is a device that stays outside of the body and is not implanted and does not penetrate the skin. Neuromodulation means that the device stimulates activity in the brain.
Primary Outcome
Parts I, II, and III of the International Parkinson and Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) evaluates motor (Parts I and III) and non-motor (Part II) experiences and complications of Parkinson's disease (PD) by which it characterizes the extent and burden of disease. Questions/evaluations are divided across Part I (13 questions, 52 possible points), Part II (13 questions, 52 possible points), Part III (33 questions based on 18 items, several with right,
Interventions
- DEVICE Non-invasive brainstem stimulation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 9 participants |
| Start Date | 2024-05-08 |
| Est. Completion | 2025-02-24 |
| Phase | NA |
Why NCT05987540 stopped before completion
NCT05987540 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 9 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 1 intervention - of which Non-invasive brainstem stimulation is the first listed.
NCT05987540 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05987540 about?
NCT05987540 is a clinical study titled "SHARPEN - Parkinson's Disease Dementia". The purpose of this single arm study is to evaluate the feasibility and safety of treatments with a non-invasive neuromodulation device in adults diagnosed with mild/moderate Parkinson's disease dementia (PDD). A non-invasive device is a device that stays outside of the body and is not implanted and...
What is the current status of trial NCT05987540?
This trial is currently terminated. It is a NA study. The enrollment target is 9 participants. The study started on 2024-05-08. Estimated completion is 2025-02-24.
What interventions are being tested in trial NCT05987540?
The interventions under investigation include: Non-invasive brainstem stimulation (DEVICE).
Who is sponsoring clinical trial NCT05987540?
This trial is sponsored by Scion NeuroStim, which has 9 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05987540's enrollment target sits among peer trials
9 1975th of 2000 higher than 25 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI