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NCT05972174 · ClinicalTrials.gov registry record · Phase 1
A Study of mRNA-1018 Pandemic Influenza Candidate Vaccines in Healthy Adults
A Phase 1 study, sponsored by ModernaTX.
- Completed
- Registry status
- Phase 1
- Development phase
- 1,504
- Enrollment target
NCT05972174: Completed Phase 1 study, sponsored by ModernaTX.
NCT05972174 is a Phase 1 study that has completed, run by ModernaTX. The registered enrollment target is 1,504 participants, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (2407% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05972174, a Phase 1 study, has completed, sponsored by ModernaTX.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 1,504 participants
- Enrollment target
Study Summary
The purpose of this Phase 1/2 study is to generate sufficient safety and immunogenicity data of mRNA-1018 pandemic influenza candidate vaccines in healthy adults ≥18 years of age to enable the initiation of a large Phase 3 trial with one selected vaccine candidate. The study will be conducted in 2 Parts (Part A and Part B) that will enroll and run concurrently. Part A of the study will evaluate 4 vaccine candidates (H5N8, H7N9, H5 only, and H7 only). Part B of the study will evaluate a single vaccine candidate (H5 only-CG).
Interventions
- BIOLOGICAL mRNA-1018 for H5N8
- BIOLOGICAL mRNA-1018 for H7N9
- BIOLOGICAL mRNA-1018 for H5 Only
- BIOLOGICAL mRNA-1018 for H7 Only
- BIOLOGICAL mRNA-1018 for H5 Only-CG
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,504 participants |
| Start Date | 2023-07-10 |
| Est. Completion | 2024-07-16 |
| Phase | Phase 1 |
What the finished NCT05972174 record still lists
NCT05972174 is an interventional study that assigns participants to a tested intervention. Its 1,504 participants enrollment target places it among the larger protocols in the corpus, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (2407% higher).
The record links to 0 conditions, and to 5 interventions - of which mRNA-1018 for H5N8 is the first listed.
NCT05972174 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05972174 about?
NCT05972174 is a clinical study titled "A Study of mRNA-1018 Pandemic Influenza Candidate Vaccines in Healthy Adults". The purpose of this Phase 1/2 study is to generate sufficient safety and immunogenicity data of mRNA-1018 pandemic influenza candidate vaccines in healthy adults ≥18 years of age to enable the initiation of a large Phase 3 trial with one selected vaccine candidate. The study will be conducted in 2 P...
What is the current status of trial NCT05972174?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 1,504 participants. The study started on 2023-07-10. Estimated completion is 2024-07-16.
What interventions are being tested in trial NCT05972174?
The interventions under investigation include: mRNA-1018 for H5N8 (BIOLOGICAL), mRNA-1018 for H7N9 (BIOLOGICAL), mRNA-1018 for H5 Only (BIOLOGICAL), mRNA-1018 for H7 Only (BIOLOGICAL), mRNA-1018 for H5 Only-CG (BIOLOGICAL).
Who is sponsoring clinical trial NCT05972174?
This trial is sponsored by ModernaTX, which has 90 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05972174's enrollment target sits among peer trials
1,504 3rd of 2000 higher than 1,998 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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