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NCT05954871 · ClinicalTrials.gov registry record · Phase 1
Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-1971 in Combination With Either Osimertinib in Participants With Unresectable, Locally Advanced, or Metastatic Non-Small Cell Lung Cancer, or With Cetuximab in Participants With Metastatic Colorectal Cancer
A Phase 1 study, sponsored by Genentech.
- Completed
- Registry status
- Phase 1
- Development phase
- 10
- Enrollment target
NCT05954871: Completed Phase 1 study, sponsored by Genentech.
NCT05954871 is a Phase 1 study that has completed, run by Genentech. The registered enrollment target is 10 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (83% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05954871, a Phase 1 study, has completed, sponsored by Genentech.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 10 participants
- Enrollment target
Study Summary
The main purpose of the study is to evaluate the safety of GDC-1971 in combination with either osimertinib or cetuximab. The study consists of a dose-finding stage followed by an expansion stage.
Interventions
- DRUG Osimertinib
- DRUG Cetuximab
- DRUG GDC-1971
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2024-01-08 |
| Est. Completion | 2025-09-16 |
| Phase | Phase 1 |
What the finished NCT05954871 record still lists
NCT05954871 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (83% lower).
The record links to 0 conditions, and to 3 interventions - of which Osimertinib is the first listed.
NCT05954871 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05954871 about?
NCT05954871 is a clinical study titled "Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-1971 in Combination With Either Osimertinib in Participants With Unresectable, Locally Advanced, or Metastatic Non-Small Cell Lung Cancer, or With Cetuximab in Participants With Metastatic Colorectal Cancer". The main purpose of the study is to evaluate the safety of GDC-1971 in combination with either osimertinib or cetuximab. The study consists of a dose-finding stage followed by an expansion stage.
What is the current status of trial NCT05954871?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 10 participants. The study started on 2024-01-08. Estimated completion is 2025-09-16.
What interventions are being tested in trial NCT05954871?
The interventions under investigation include: Osimertinib (DRUG), Cetuximab (DRUG), GDC-1971 (DRUG).
Who is sponsoring clinical trial NCT05954871?
This trial is sponsored by Genentech, which has 332 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05954871's enrollment target sits among peer trials
10 1913th of 2000 higher than 46 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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