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NCT05946278 · ClinicalTrials.gov registry record
Genetic Regulators of Bone Health That Are Unique to Vertebral Bone
A clinical trial of Age-Related Osteoporosis, sponsored by University of Colorado, Denver.
- Recruiting
- Registry status
- 550
- Enrollment target
- 1
- Study location
NCT05946278 is a study of Age-Related Osteoporosis that is actively recruiting participants, run by University of Colorado, Denver. The registered enrollment target is 550 participants. The trial reports 1 study location across 1 state.
The verdict
NCT05946278, a study of Age-Related Osteoporosis, is actively recruiting participants, sponsored by University of Colorado, Denver.
- RECRUITING
- Registry status
- 550 participants
- Enrollment target
- 1
- Study location
Study Summary
Osteoporosis is an age related disease in which a person's bone slowly becomes weaker with time. The bones may become so weak that they break easily such as a fall from standing height. The most commonly broke bones in osteoporosis are those of the hip, the spine or the wrist. Osteoporosis runs in families meaning that genetic differences explain why some people break bones in old age and other do not. Genetic studies have been done that show the the genes associated with spine (vertebral) fractures (broken bones) and hip fractures are different, suggesting that osteoporosis of the spine is not the exact same disease as osteoporosis of the hip. Genetic studies tell us what part of the genome (i.e. genes) are associated with a disease, but do not tell us how these genes act biologically to cause that disease. In this study, we seek to determine how the genes uniquely associated with spine osteoporosis behave in normal and aged bone, to determine how they interact with each other as a team to impact spine bone. In this study, we will measure gene activity (so called gene expression) in bone samples taken from people undergoing major spine deformity surgery. We will using genetic data from these patients to determine how gene activity is controlled in bone and how that relates to measures of bone health such as bone mineral density data. The results of this study will provide critical data regarding how osteoporosis of the spine happens, and these data will be used to find better and safer treatments to prevent bone fractures of the spine that happen with age.
Conditions Studied
Interventions
- OTHER Sample collection for gene expression
Study Locations (1)
Colorado
- Univeristy of Colorado Denver - Aurora
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 550 participants |
| Start Date | 2024-04 |
| Est. Completion | 2030-08-30 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05946278
The ClinicalTrials.gov registry entry for NCT05946278 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 550 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Colorado, Denver, which has 1,283 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Age-Related Osteoporosis appearing as the primary indexed condition, and to 1 intervention - of which Sample collection for gene expression is the first listed.
NCT05946278 reports 1 study location spanning 1 distinct geographic area - top geographies include Colorado.
Frequently Asked Questions
What is clinical trial NCT05946278 about?
NCT05946278 is a clinical study titled "Genetic Regulators of Bone Health That Are Unique to Vertebral Bone". Osteoporosis is an age related disease in which a person's bone slowly becomes weaker with time. The bones may become so weak that they break easily such as a fall from standing height. The most commonly broke bones in osteoporosis are those of the hip, the spine or the wrist. Osteoporosis runs in f...
What is the current status of trial NCT05946278?
This trial is currently recruiting. The enrollment target is 550 participants. The study started on 2024-04. Estimated completion is 2030-08-30.
What conditions does trial NCT05946278 study?
This clinical trial studies the following conditions: Age-Related Osteoporosis.
What interventions are being tested in trial NCT05946278?
The interventions under investigation include: Sample collection for gene expression (OTHER).
Who is sponsoring clinical trial NCT05946278?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05946278 being conducted?
This trial has 1 study location across Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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