Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05936619 · ClinicalTrials.gov registry record · NA
MindEx: A Novel, Multifocal, Cognitive Brain-Machine Interface System
A NA study of Paralysis; Quadriplegic, sponsored by Nader Pouratian.
- Recruiting
- Registry status
- NA
- Development phase
- 2
- Enrollment target
- 1
- Study location
NCT05936619: Recruiting NA study of Paralysis; Quadriplegic, sponsored by Nader Pouratian.
NCT05936619 is a NA study of Paralysis; Quadriplegic that is actively recruiting participants, run by Nader Pouratian. The registered enrollment target is 2 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05936619, a NA study of Paralysis; Quadriplegic, is actively recruiting participants, sponsored by Nader Pouratian.
- RECRUITING
- Registry status
- NA
- Development phase
- 2 participants
- Enrollment target
- 1
- Study location
Study Summary
This research study is being done to develop a novel brain-computer interface (BCI) technology that can enable severely paralyzed individuals to interact with the world through direct brain-control of a computer. This technology is named MindEx (for Mind Extender). It utilizes four implanted "chips" in the human brain from which investigators can record brain activity during subjects' thoughts and decode meaningful information from this activity to be used as control signals for a computer, a laptop, or a tablet. The use of four brain regions is a significant differentiating feature and scientific innovation of this study over much prior work in this space, that typically derived control signals from one, or sometimes two brain regions. The brain regions to be used here can allow the decode of multiple variables simultaneously, including not just moment-to-moment position, but also high-level goals, intentions, decisions, scene comprehension, and error-related signals involved in natural human behavior. The research is being done through a prospective, longitudinal, single-arm early feasibility study to examine the safety and effectiveness of using MindEx to provide the user an intuitive, efficient, and accurate ability to control multiple applications on a computer interface such as a word processor, a paint application, or to play simple video games. Such versatility could greatly improve the autonomy and quality of life of severely paralyzed individuals. Two subjects will be enrolled, each implanted with MindEx for a period of at least 53 weeks and up to 313 weeks. The study is expected to take at least one year and up to six years in total.
Primary Outcome
A primary objective of this study is to evaluate the effectiveness of the system in providing users the ability to continuously move a cursor on a tablet/computer. The hypothesis is that trajectory readability from neural signals will be significantly greater than the level of chance. Standardized tests will be used to test this objective, and performance will be compared to the level of chance. One example of a standardized test to be used is the accuracy of continuous trajectory decoding me
Conditions Studied
Interventions
- DEVICE Mind Extender (MindEx)
Study Locations (1)
Texas
- UT Southwestern Medical Center - Dallas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2 participants |
| Start Date | 2026-02-20 |
| Est. Completion | 2031-09-01 |
| Phase | NA |
What NCT05936619 shows while recruiting
NCT05936619 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 2 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower).
The record links to 1 condition, with Paralysis; Quadriplegic appearing as the primary indexed condition, and to 1 intervention - of which Mind Extender (MindEx) is the first listed.
NCT05936619 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT05936619 about?
NCT05936619 is a clinical study titled "MindEx: A Novel, Multifocal, Cognitive Brain-Machine Interface System". This research study is being done to develop a novel brain-computer interface (BCI) technology that can enable severely paralyzed individuals to interact with the world through direct brain-control of a computer. This technology is named MindEx (for Mind Extender). It utilizes four implanted "chips"...
What is the current status of trial NCT05936619?
This trial is currently recruiting. It is a NA study. The enrollment target is 2 participants. The study started on 2026-02-20. Estimated completion is 2031-09-01.
What conditions does trial NCT05936619 study?
This clinical trial studies the following conditions: Paralysis; Quadriplegic.
What interventions are being tested in trial NCT05936619?
The interventions under investigation include: Mind Extender (MindEx) (DEVICE).
Who is sponsoring clinical trial NCT05936619?
This trial is sponsored by Nader Pouratian, which has 3 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05936619 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05936619's enrollment target sits among peer trials
2 1997th of 2000 the lowest of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI