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NCT05929729 · ClinicalTrials.gov registry record · Phase 4
Iron Deficiency Anemia (IDA) and the Brain
A Phase 4 study of Anemia and Iron Deficiency Anemia, sponsored by Children's Hospital Los Angeles.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 120
- Enrollment target
- 4
- Study locations
NCT05929729: Recruiting Phase 4 study of Anemia and Iron Deficiency Anemia, sponsored by Children's Hospital Los Angeles.
NCT05929729 is a Phase 4 study of Anemia and Iron Deficiency Anemia that is actively recruiting participants, run by Children's Hospital Los Angeles. The registered enrollment target is 120 participants, below the 426-participant average among 72 other Anemia trials with a reported enrollment target (72% lower). The trial reports 4 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05929729, a Phase 4 study of Anemia and Iron Deficiency Anemia, is actively recruiting participants, sponsored by Children's Hospital Los Angeles.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 120 participants
- Enrollment target
- 4
- Study locations
Study Summary
This is a trial with an observational and an interventional arm, in patients with moderate to severe anemia and control subjects. The main purposes of this study is to phenotype the scope of neurocognitive deficits from iron deficiency anemia (IDA) in adult women, determine derangements in cerebral perfusion, vascular reactivity, functional connectivity, and blood brain barrier permeability in adult-onset IDA and relate them to neurocognitive deficits, as well as determine the reversibility and durability of both the physiologic and neurocognitive derangements by iron replacement therapy. All eligible subjects will be asked to provide informed consent before participating in the study.
Primary Outcome
Baseline impact of iron deficiency anemia on cerebrovascular oxygen delivery will be assessed by measuring cerebral blood flow and oxygen content through MRI (time-encoded arterial spin labelling) and peripheral blood sample
Conditions Studied
Interventions
- DRUG Ferric derisomaltose
- DRUG NovaFerrum
Study Locations (4)
California
- City of Hope Blood Donor Center - Duarte
- Cedar Sinai Blood Bank - Los Angeles
- Children's Hospital Los Angeles - Los Angeles
- University of California, Los Angeles Blood Donor Center - Los Angeles
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2023-12-07 |
| Est. Completion | 2028-09-01 |
| Phase | Phase 4 |
What NCT05929729 shows while recruiting
NCT05929729 is an interventional study that assigns participants to a tested intervention. The registered 120 participants enrollment target is mid-sized for trials with a published cap, below the 426-participant average among 72 other Anemia trials with a reported enrollment target (72% lower).
The record links to 4 conditions, with Anemia appearing as the primary indexed condition, and to 2 interventions - of which Ferric derisomaltose is the first listed.
NCT05929729 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT05929729 about?
NCT05929729 is a clinical study titled "Iron Deficiency Anemia (IDA) and the Brain". This is a trial with an observational and an interventional arm, in patients with moderate to severe anemia and control subjects. The main purposes of this study is to phenotype the scope of neurocognitive deficits from iron deficiency anemia (IDA) in adult women, determine derangements in cerebral ...
What is the current status of trial NCT05929729?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 120 participants. The study started on 2023-12-07. Estimated completion is 2028-09-01.
What conditions does trial NCT05929729 study?
This clinical trial studies the following conditions: Anemia, Iron Deficiency Anemia, Anemia, Iron Deficiency, IDA - Iron Deficiency Anemia.
What interventions are being tested in trial NCT05929729?
The interventions under investigation include: Ferric derisomaltose (DRUG), NovaFerrum (DRUG).
Who is sponsoring clinical trial NCT05929729?
This trial is sponsored by Children's Hospital Los Angeles, which has 119 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05929729 being conducted?
This trial has 4 study locations across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Anemia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05929729's enrollment target sits among peer trials
120 43rd of 72 higher than 30 of 72 other Anemia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Anemia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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