Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05905224 · ClinicalTrials.gov registry record · NA
Clinical Trial to Assess the Efficacy of Reducing the Aligners' Wear Protocol
A NA study of Orthodontic Tooth Movement, sponsored by University of Florida.
- Active
- Registry status
- NA
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT05905224: Active NA study of Orthodontic Tooth Movement, sponsored by University of Florida.
NCT05905224 is a NA study of Orthodontic Tooth Movement that is active but no longer recruiting, run by University of Florida. The registered enrollment target is 40 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05905224, a NA study of Orthodontic Tooth Movement, is active but no longer recruiting, sponsored by University of Florida.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
The hypothesis of this project is that replacing the current 7-day wear protocol with a 3-day wear protocol, while integrating less tooth movement per aligner (reduce the amount of activation per aligner) may produce more consistent and continues orthodontic forces, therefore, increase the predictability, accuracy and outcomes achieved for various types of tooth movements and enhance the rate of tooth movement with the Invisalign system
Primary Outcome
assess the influence of reducing the wear scheduled for Invisalign clear aligners, from 7- day wear to 3-day wear, on the predictability and accuracy of different orthodontic tooth movements by comparing the simulated predicted final outcomes to those achieved at the end of treatment between the two wear protocols.
Conditions Studied
Interventions
- DEVICE Invisalign 7-day wear protocol
- DEVICE Invisalign 3-day wear protocol
Study Locations (1)
Florida
- University of Florida _ Department of Orthodontics - Gainesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2023-10-30 |
| Est. Completion | 2028-08 |
| Phase | NA |
What the registry record for NCT05905224 still lists
NCT05905224 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 1 condition, with Orthodontic Tooth Movement appearing as the primary indexed condition, and to 2 interventions - of which Invisalign 7-day wear protocol is the first listed.
NCT05905224 reports a single indexed study location in Florida.
Frequently Asked Questions
What is clinical trial NCT05905224 about?
NCT05905224 is a clinical study titled "Clinical Trial to Assess the Efficacy of Reducing the Aligners' Wear Protocol". The hypothesis of this project is that replacing the current 7-day wear protocol with a 3-day wear protocol, while integrating less tooth movement per aligner (reduce the amount of activation per aligner) may produce more consistent and continues orthodontic forces, therefore, increase the predictab...
What is the current status of trial NCT05905224?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 40 participants. The study started on 2023-10-30. Estimated completion is 2028-08.
What conditions does trial NCT05905224 study?
This clinical trial studies the following conditions: Orthodontic Tooth Movement.
What interventions are being tested in trial NCT05905224?
The interventions under investigation include: Invisalign 7-day wear protocol (DEVICE), Invisalign 3-day wear protocol (DEVICE).
Who is sponsoring clinical trial NCT05905224?
This trial is sponsored by University of Florida, which has 1,106 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05905224 being conducted?
This trial has 1 study location across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05905224's enrollment target sits among peer trials
40 1447th of 2000 higher than 465 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01306019 · 40 participants · Phase 1
Lentiviral Gene Transfer for Treatment of Children Older Than Two Years of Age With X-Linked Severe Combined Immunodeficiency (XSCID)
- NCT01608152 · 40 participants
Development of a Video Game for the Improvement of Outcomes in Stem Cell Transplant Survivors
- NCT01668082 · 40 participants · NA
An Investigation of Brain Tumor Metabolism in Patients Undergoing Surgical Resection
- NCT02015013 · 40 participants · Phase 2
Hematopoietic Stem Cell Mobilization in Idiopathic CD4 Lymphocytopenia Patients and Healthy Controls for the Study of T Cell Maturation and Trafficking in Murine Models
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI