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NCT05888207 · ClinicalTrials.gov registry record · Phase 1
A Study to Assess the Effects of Fluvoxamine on Savolitinib Exposure in Healthy Male Subjects
A Phase 1 study, sponsored by AstraZeneca.
- Completed
- Registry status
- Phase 1
- Development phase
- 16
- Enrollment target
NCT05888207: Completed Phase 1 study, sponsored by AstraZeneca.
NCT05888207 is a Phase 1 study that has completed, run by AstraZeneca. The registered enrollment target is 16 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (73% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05888207, a Phase 1 study, has completed, sponsored by AstraZeneca.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 16 participants
- Enrollment target
Study Summary
This study will assess the effects of strong CYP1A2 (Cytochrome P450 1A2) inhibitor (fluvoxamine) on savolitinib exposure in healthy male subjects, performed at a single clinical unit.
Primary Outcome
To evaluate the effects of fluvoxamine on savolitinib Cmax in healthy male subjects after administration of a single oral dose.
Interventions
- DRUG Fluvoxamine
- DRUG Savolitinib
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 16 participants |
| Start Date | 2023-06-02 |
| Est. Completion | 2023-08-17 |
| Phase | Phase 1 |
What the finished NCT05888207 record still lists
NCT05888207 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 16 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (73% lower).
The record links to 0 conditions, and to 2 interventions - of which Fluvoxamine is the first listed.
NCT05888207 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05888207 about?
NCT05888207 is a clinical study titled "A Study to Assess the Effects of Fluvoxamine on Savolitinib Exposure in Healthy Male Subjects". This study will assess the effects of strong CYP1A2 (Cytochrome P450 1A2) inhibitor (fluvoxamine) on savolitinib exposure in healthy male subjects, performed at a single clinical unit.
What is the current status of trial NCT05888207?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 16 participants. The study started on 2023-06-02. Estimated completion is 2023-08-17.
What interventions are being tested in trial NCT05888207?
The interventions under investigation include: Fluvoxamine (DRUG), Savolitinib (DRUG).
Who is sponsoring clinical trial NCT05888207?
This trial is sponsored by AstraZeneca, which has 1,285 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05888207's enrollment target sits among peer trials
16 1786th of 2000 higher than 203 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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