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NCT05880355 · ClinicalTrials.gov registry record · Early Phase 1
Multimodality Cardiovascular Imaging for the Translation of Therapies for Vascular Activation After MI
A Early Phase 1 study, sponsored by University of Virginia.
- Not yet
- Registry status
- Early Phase 1
- Development phase
- 60
- Enrollment target
NCT05880355: Clinical Trial Early Phase 1 study, sponsored by University of Virginia.
NCT05880355 is a Early Phase 1 study that has not yet begun recruiting, run by University of Virginia. The registered enrollment target is 60 participants, above the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (13% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05880355, a Early Phase 1 study, has not yet begun recruiting, sponsored by University of Virginia.
- NOT YET RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 60 participants
- Enrollment target
Study Summary
Subjects with urgently reperfused type I myocardial infarction (MI) will be recruited and randomized to receive either placebo or the oral inflammasome (NLRP3) inhibitor dapansutrile. The primarily outcome measure will be carotid plaque volume change over 6 months; secondary outcome measures will be plaque inflammatory activity and coronary microvascular function.
Primary Outcome
Carotid artery plaque volume change by ultrasound measured by 3D ultrasound. Outcome units will be cm3 averaged for bilateral carotid arteries.
Interventions
- OTHER Placebo
- DRUG Dapansutrile
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2026-04-01 |
| Est. Completion | 2029-01-30 |
| Phase | Early Phase 1 |
What is known before NCT05880355 opens enrollment
NCT05880355 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, above the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (13% higher).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT05880355 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05880355 about?
NCT05880355 is a clinical study titled "Multimodality Cardiovascular Imaging for the Translation of Therapies for Vascular Activation After MI". Subjects with urgently reperfused type I myocardial infarction (MI) will be recruited and randomized to receive either placebo or the oral inflammasome (NLRP3) inhibitor dapansutrile. The primarily outcome measure will be carotid plaque volume change over 6 months; secondary outcome measures will be...
What is the current status of trial NCT05880355?
This trial is currently not yet recruiting. It is a Early Phase 1 study. The enrollment target is 60 participants. The study started on 2026-04-01. Estimated completion is 2029-01-30.
What interventions are being tested in trial NCT05880355?
The interventions under investigation include: Placebo (OTHER), Dapansutrile (DRUG).
Who is sponsoring clinical trial NCT05880355?
This trial is sponsored by University of Virginia, which has 449 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05880355's enrollment target sits among peer trials
60 403rd of 2000 higher than 1,564 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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