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NCT05878873 · ClinicalTrials.gov registry record · NA
The Neural Mechanisms of Split-belt Treadmill Adaptation in People With Multiple Sclerosis
A NA study, sponsored by Colorado State University.
- Completed
- Registry status
- NA
- Development phase
- 51
- Enrollment target
NCT05878873: Completed NA study, sponsored by Colorado State University.
NCT05878873 is a NA study that has completed, run by Colorado State University. The registered enrollment target is 51 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05878873, a NA study, has completed, sponsored by Colorado State University.
- COMPLETED
- Registry status
- NA
- Development phase
- 51 participants
- Enrollment target
Study Summary
Majority of people with multiple sclerosis experience difficulty with balance and mobility, leading to an increased risk of falls. The goal of this clinical trial is to learn about brain activity during walking adaptation in people with multiple sclerosis. Also, this clinical trial will test a form of nerve stimulation to see if it can improve walking performance. The main questions it aims to answer are: * What areas of the brain are the most active during walking adaptation? * Can nerve stimulation make walking adaptation more effective? Participants will walk on a treadmill where each leg will go a different speed which will create walking adaptation. At the same time, brain scans will occur. There will be two sessions of walking adaptation, one with nerve stimulation, and one without nerve stimulation. Researchers will compare people with multiple sclerosis to healthy young adults to see if there are differences in brain activity.
Primary Outcome
Cortical activation is measured using functional near-infrared spectroscopy (fNIRS) during split-belt treadmill walking. Hemodynamic responses are modeled using a general linear model (GLM) applied to the oxyhemoglobin (HbO) signal. The model includes regressors for distinct phases of walking, with the primary contrast comparing early adaptation (strides 6-30 after split-belt onset) to a baseline walking period. The outcome is defined as the difference in this HbO beta weight contrast with TENS
Interventions
- DEVICE Transcutaneous Electrical Nerve Stimulation (TENS)
- BEHAVIORAL Split-belt Treadmill
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 51 participants |
| Start Date | 2023-11-28 |
| Est. Completion | 2024-06-30 |
| Phase | NA |
What the finished NCT05878873 record still lists
NCT05878873 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 51 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 2 interventions - of which Transcutaneous Electrical Nerve Stimulation (TENS) is the first listed.
NCT05878873 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05878873 about?
NCT05878873 is a clinical study titled "The Neural Mechanisms of Split-belt Treadmill Adaptation in People With Multiple Sclerosis". Majority of people with multiple sclerosis experience difficulty with balance and mobility, leading to an increased risk of falls. The goal of this clinical trial is to learn about brain activity during walking adaptation in people with multiple sclerosis. Also, this clinical trial will test a form ...
What is the current status of trial NCT05878873?
This trial is currently completed. It is a NA study. The enrollment target is 51 participants. The study started on 2023-11-28. Estimated completion is 2024-06-30.
What interventions are being tested in trial NCT05878873?
The interventions under investigation include: Transcutaneous Electrical Nerve Stimulation (TENS) (DEVICE), Split-belt Treadmill (BEHAVIORAL).
Who is sponsoring clinical trial NCT05878873?
This trial is sponsored by Colorado State University, which has 94 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05878873's enrollment target sits among peer trials
51 1279th of 2000 higher than 722 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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