Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05869747 · ClinicalTrials.gov registry record · NA
Firefighter Collaborative Research Project
A NA study of Cardiopulmonary and Exposure, sponsored by University of Arizona.
- Active
- Registry status
- NA
- Development phase
- 1,500
- Enrollment target
- 7
- Study locations
NCT05869747: Active NA study of Cardiopulmonary and Exposure, sponsored by University of Arizona.
NCT05869747 is a NA study of Cardiopulmonary and Exposure that is active but no longer recruiting, run by University of Arizona. The registered enrollment target is 1,500 participants, roughly in line with the 1,404-participant average among 58,714 other NA trials with a reported enrollment target. The trial reports 7 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05869747, a NA study of Cardiopulmonary and Exposure, is active but no longer recruiting, sponsored by University of Arizona.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 1,500 participants
- Enrollment target
- 7
- Study locations
Study Summary
The goal of this research is to test interventions to reduce firefighter cardiovascular, cognitive, and overall disease risks, including but not limited to risks associated with Per- and Polyfluorinated Substances (PFAS) exposure. Approximately 1,500 - 2,000 firefighters will be enrolled in the Fire Fighter Cancer Cohort Study (FFCCS). Among these individuals, those that express interest will then be screened for eligibility for the Firefighter Collaborative Research Project (FCRP) using information they provided for the Fire Fighter Cancer Cohort Study. Firefighters enrolled in the study will provide an initial blood sample and urine sample. The blood sample will be analyzed to determine the participant's PFAS levels. Based upon serum PFAS levels and responses from the screening survey, eligible participants will be randomly assigned into one of the following interventions: 1. Blood Donation, or Plasma Donation or Blood/Plasma Control Group; 2. Zone 2 Training or Zone 2 Control; 3. Intermittent Fasting or Intermittent Fasting Control. Individuals participating in the blood donation, plasma donation or blood/plasma control group would donate blood every 12 weeks, plasma every 6 weeks, or not donate blood or plasma. Participants in this intervention arm would continue this for a 12-month period. Individuals in the zone 2 training, zone 2 training control, intermittent fasting or intermittent fasting control group would participate in their intervention or control for a 4-month period. After 4 to 12 months participating in an intervention or control group, participants will be asked to provide a final urine sample and blood draw to determine if and to what degree their PFAS levels or other cardiovascular disease and other health risks have changed.
Primary Outcome
PFAS levels are per- and polyfluoroalkyl substance levels measured from a biological sample
Conditions Studied
Interventions
- BEHAVIORAL Surveys
- BEHAVIORAL Intermittent Fasting
- BEHAVIORAL Blood Donation
- BEHAVIORAL Plasma Donation
- BEHAVIORAL Zone 2 Training
Study Locations (7)
Arizona
- Gilbert Fire & Rescue Department - Gilbert
- Green Valley Fire - Green Valley
- Tucson Fire Department Headquarters - Tucson
- Tucson Fire Department Station 9 - Tucson
- University of Arizona - Tucson
- Northwest Fire District - Tucson
- Drexel Heights Fire - Tucson
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,500 participants |
| Start Date | 2023-06-22 |
| Est. Completion | 2025-12-31 |
| Phase | NA |
What the registry record for NCT05869747 still lists
NCT05869747 is an interventional study that assigns participants to a tested intervention. Its 1,500 participants enrollment target places it among the larger protocols in the corpus, roughly in line with the 1,404-participant average among 58,714 other NA trials with a reported enrollment target.
The record links to 2 conditions, with Cardiopulmonary appearing as the primary indexed condition, and to 5 interventions - of which Surveys is the first listed.
NCT05869747 lists 7 locations in 1 state (Arizona).
Frequently Asked Questions
What is clinical trial NCT05869747 about?
NCT05869747 is a clinical study titled "Firefighter Collaborative Research Project". The goal of this research is to test interventions to reduce firefighter cardiovascular, cognitive, and overall disease risks, including but not limited to risks associated with Per- and Polyfluorinated Substances (PFAS) exposure. Approximately 1,500 - 2,000 firefighters will be enrolled in the Fire...
What is the current status of trial NCT05869747?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 1,500 participants. The study started on 2023-06-22. Estimated completion is 2025-12-31.
What conditions does trial NCT05869747 study?
This clinical trial studies the following conditions: Cardiopulmonary, Exposure.
What interventions are being tested in trial NCT05869747?
The interventions under investigation include: Surveys (BEHAVIORAL), Intermittent Fasting (BEHAVIORAL), Blood Donation (BEHAVIORAL), Plasma Donation (BEHAVIORAL), Zone 2 Training (BEHAVIORAL).
Who is sponsoring clinical trial NCT05869747?
This trial is sponsored by University of Arizona, which has 349 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05869747 being conducted?
This trial has 7 study locations across Arizona. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cardiopulmonary
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05869747's enrollment target sits among peer trials
1,500 65th of 2000 higher than 1,933 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00178724 · 1,500 participants
Spinal Cord Injury Registry - North American Clinical Trials Network
- NCT00951366 · 1,500 participants
Preterm Lung Patient Registry
- NCT01050504 · 1,500 participants
Collecting and Studying Blood and Tissue Samples From Patients With Locally Recurrent or Metastatic Prostate or Bladder/Urothelial Cancer
- NCT02071134 · 1,500 participants
Registry of Deep Brain Stimulation With the VERCISE™ System: Vercise DBS Registry
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI