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NCT05866731 · ClinicalTrials.gov registry record
The Heart Rhythm Twins Study
A clinical trial, sponsored by University of California, San Francisco.
- Completed
- Registry status
- 156
- Enrollment target
NCT05866731: Completed study, sponsored by University of California, San Francisco.
NCT05866731 is a clinical trial that has completed, run by University of California, San Francisco. The registered enrollment target is 156 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05866731 has completed, sponsored by University of California, San Francisco.
- COMPLETED
- Registry status
- 156 participants
- Enrollment target
Study Summary
Premature atrial contractions (PACs) and premature ventricular contractions (PVCs) are observed in the majority of individuals monitored for more than a few hours. Although the clinical course of PACs and PVCs is usually benign, it has been described that high PAC or PVC frequency causes various comorbidities and worsens outcomes in different patient groups. For example, PACs can initiate episodes of atrial fibrillation, and PAC count is highly specific in predicting diagnosis of incident atrial fibrillation. Increasing PVC frequencies are an important predictor of incident heart failure. While conventional wisdom dictates that common environmental exposures determine PAC and PVC frequencies, this has not born out in rigorous studies. Whether PAC and PVC frequencies may have genetic underpinnings remains unknown. Comparisons between identical twins and fraternal twins can provide estimates of heritability. Fraternal twins are an ideal control because, like identical twins, they share a womb, have the same birthday, and their environment while growing up are as similar as between identical twins. However, while identical twins share approximately 100% of the same inherited DNA, fraternal twins share, on average, about 50%. By monitoring identical and fraternal twins with portable electrocardiograms (ECGs), we will be able to count the PACs and PVCs over a consecutive timespan to describe the familial aggregation of these complexes. This, to our knowledge, would be the first study to compare PAC and PVC frequencies in identical and same-sex fraternal twins, providing the first assessment of how genetical inheritance may influence cardiac ectopy burdens.
Primary Outcome
This will be measured using a wearable EKG monitor.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 156 participants |
| Start Date | 2022-03-22 |
| Est. Completion | 2025-08-18 |
What the finished NCT05866731 record still lists
NCT05866731 is an observational study that tracks outcomes without assigning an intervention. The registered 156 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 0 interventions.
NCT05866731 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05866731 about?
NCT05866731 is a clinical study titled "The Heart Rhythm Twins Study". Premature atrial contractions (PACs) and premature ventricular contractions (PVCs) are observed in the majority of individuals monitored for more than a few hours. Although the clinical course of PACs and PVCs is usually benign, it has been described that high PAC or PVC frequency causes various com...
What is the current status of trial NCT05866731?
This trial is currently completed. The enrollment target is 156 participants. The study started on 2022-03-22. Estimated completion is 2025-08-18.
Who is sponsoring clinical trial NCT05866731?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
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