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NCT05824143 · ClinicalTrials.gov registry record · Phase 1
Open-label Trial to Evaluate the Effect Carbamazepine on Darigabat Pharmacokinetics in Healthy Adult Participants
A Phase 1 study, sponsored by Cerevel Therapeutics.
- Completed
- Registry status
- Phase 1
- Development phase
- 13
- Enrollment target
NCT05824143: Completed Phase 1 study, sponsored by Cerevel Therapeutics.
NCT05824143 is a Phase 1 study that has completed, run by Cerevel Therapeutics. The registered enrollment target is 13 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (78% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05824143, a Phase 1 study, has completed, sponsored by Cerevel Therapeutics.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 13 participants
- Enrollment target
Study Summary
The primary purpose of the study is to evaluate the effect of increased metabolizing enzyme (cytochrome P450 \[CYP\] 3A4) due to carbamazepine, a strong CYP3A4 inducer, on the pharmacokinetics (PK) of darigabat in healthy adult participants.
Primary Outcome
PK of darigabat will be analyzed both in the presence and absence of carbamazepine.
Interventions
- DRUG Carbamazepine
- DRUG Darigabat
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 13 participants |
| Start Date | 2023-04-17 |
| Est. Completion | 2023-07-07 |
| Phase | Phase 1 |
What the finished NCT05824143 record still lists
NCT05824143 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 13 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (78% lower).
The record links to 0 conditions, and to 2 interventions - of which Carbamazepine is the first listed.
NCT05824143 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05824143 about?
NCT05824143 is a clinical study titled "Open-label Trial to Evaluate the Effect Carbamazepine on Darigabat Pharmacokinetics in Healthy Adult Participants". The primary purpose of the study is to evaluate the effect of increased metabolizing enzyme (cytochrome P450 \[CYP\] 3A4) due to carbamazepine, a strong CYP3A4 inducer, on the pharmacokinetics (PK) of darigabat in healthy adult participants.
What is the current status of trial NCT05824143?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 13 participants. The study started on 2023-04-17. Estimated completion is 2023-07-07.
What interventions are being tested in trial NCT05824143?
The interventions under investigation include: Carbamazepine (DRUG), Darigabat (DRUG).
Who is sponsoring clinical trial NCT05824143?
This trial is sponsored by Cerevel Therapeutics, which has 21 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05824143's enrollment target sits among peer trials
13 1847th of 2000 higher than 149 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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