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NCT05761301 · ClinicalTrials.gov registry record · Phase 1
A Phase 1/2 Study to Evaluate ALN-KHK in Overweight to Obese Healthy Volunteers and Obese Patients With T2DM
A Phase 1 study, sponsored by Alnylam Pharmaceuticals.
- Terminated
- Registry status
- Phase 1
- Development phase
- 49
- Enrollment target
NCT05761301: Clinical Trial Phase 1 study, sponsored by Alnylam Pharmaceuticals.
NCT05761301 is a Phase 1 study that was terminated before completion, run by Alnylam Pharmaceuticals. The registered enrollment target is 49 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (18% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05761301, a Phase 1 study, was terminated before completion, sponsored by Alnylam Pharmaceuticals.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 49 participants
- Enrollment target
Study Summary
To evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of single ascending doses of ALN-KHK and to evaluate the safety, tolerability, efficacy, PK and PD of multiple doses of KHK.
Interventions
- DRUG Placebo
- DRUG ALN-KHK
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 49 participants |
| Start Date | 2023-03-10 |
| Est. Completion | 2025-04-03 |
| Phase | Phase 1 |
Why NCT05761301 stopped before completion
NCT05761301 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 49 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (18% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT05761301 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05761301 about?
NCT05761301 is a clinical study titled "A Phase 1/2 Study to Evaluate ALN-KHK in Overweight to Obese Healthy Volunteers and Obese Patients With T2DM". To evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of single ascending doses of ALN-KHK and to evaluate the safety, tolerability, efficacy, PK and PD of multiple doses of KHK.
What is the current status of trial NCT05761301?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 49 participants. The study started on 2023-03-10. Estimated completion is 2025-04-03.
What interventions are being tested in trial NCT05761301?
The interventions under investigation include: Placebo (DRUG), ALN-KHK (DRUG).
Who is sponsoring clinical trial NCT05761301?
This trial is sponsored by Alnylam Pharmaceuticals, which has 49 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05761301's enrollment target sits among peer trials
49 1017th of 2000 higher than 976 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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