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NCT05748834 · ClinicalTrials.gov registry record · Phase 2
Study of Tucatinib and Doxil in Participants With Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Metastatic Breast Cancer
A Phase 2 study of Breast Cancer, sponsored by SCRI Development Innovations.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 36
- Enrollment target
- 8
- Study locations
NCT05748834: Recruiting Phase 2 study of Breast Cancer, sponsored by SCRI Development Innovations.
NCT05748834 is a Phase 2 study of Breast Cancer that is actively recruiting participants, run by SCRI Development Innovations. The registered enrollment target is 36 participants, below the 2,803-participant average among 1,224 other Breast Cancer trials with a reported enrollment target (99% lower). The trial reports 8 study locations across 5 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05748834, a Phase 2 study of Breast Cancer, is actively recruiting participants, sponsored by SCRI Development Innovations.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 36 participants
- Enrollment target
- 8
- Study locations
Study Summary
This clinical trial is evaluating tucatinib in combination with Doxil in participants with human epidermal growth factor 2 positive (HER2+) locally advanced or metastatic breast cancer. The main goals of this study are to: * Learn how well the combination of tucatinib and Doxil works * Learn more about the side effects of the combination of tucatinib and Doxil
Primary Outcome
Proportion of participants with confirmed complete response (CR) or partial response (PR) to tucatinib in combination with Doxil according to RECIST v1.1 criteria.
Conditions Studied
Interventions
- DRUG Tucatinib
- DRUG Doxil
Study Locations (8)
Tennessee
- SCRI Oncology Partners - Nashville
- Tennessee Oncology - Nashville
Texas
- Texas Oncology- DFW - Dallas
- Texas Oncology- San Antonio - San Antonio
Virginia
- Virginia Oncology Associates - Norfolk
- Blue Ridge Cancer Care (Oncology & Hematology Assoc of SW Virginia, Inc) - Salem
Maryland
- Maryland Oncology Hematology - Columbia
Pennsylvania
- Alliance Cancer Specialists - Bensalem
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 36 participants |
| Start Date | 2023-07-24 |
| Est. Completion | 2027-11 |
| Phase | Phase 2 |
What NCT05748834 shows while recruiting
NCT05748834 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 36 participants, a relatively small participant target, below the 2,803-participant average among 1,224 other Breast Cancer trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Breast Cancer appearing as the primary indexed condition, and to 2 interventions - of which Tucatinib is the first listed.
NCT05748834 lists 8 locations in 5 states (Tennessee, Texas, Virginia).
Frequently Asked Questions
What is clinical trial NCT05748834 about?
NCT05748834 is a clinical study titled "Study of Tucatinib and Doxil in Participants With Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Metastatic Breast Cancer". This clinical trial is evaluating tucatinib in combination with Doxil in participants with human epidermal growth factor 2 positive (HER2+) locally advanced or metastatic breast cancer. The main goals of this study are to: * Learn how well the combination of tucatinib and Doxil works * Learn more a...
What is the current status of trial NCT05748834?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 36 participants. The study started on 2023-07-24. Estimated completion is 2027-11.
What conditions does trial NCT05748834 study?
This clinical trial studies the following conditions: Breast Cancer.
What interventions are being tested in trial NCT05748834?
The interventions under investigation include: Tucatinib (DRUG), Doxil (DRUG).
Who is sponsoring clinical trial NCT05748834?
This trial is sponsored by SCRI Development Innovations, which has 146 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05748834 being conducted?
This trial has 8 study locations across Maryland, Pennsylvania, Tennessee, Texas, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Breast Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05748834's enrollment target sits among peer trials
36 916th of 1224 higher than 304 of 1,224 other Breast Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Breast Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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