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NCT05746481 · ClinicalTrials.gov registry record · Phase 2
Tiragolumab and Atezolizumab in Patients With Non-squamous Non-small Cell Lung Cancer (NSCLC) and Untreated Brain Metastases
A Phase 2 study, sponsored by Liza Villaruz, MD.
- Terminated
- Registry status
- Phase 2
- Development phase
- 3
- Enrollment target
NCT05746481: Clinical Trial Phase 2 study, sponsored by Liza Villaruz, MD.
NCT05746481 is a Phase 2 study that was terminated before completion, run by Liza Villaruz, MD. The registered enrollment target is 3 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05746481, a Phase 2 study, was terminated before completion, sponsored by Liza Villaruz, MD.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 3 participants
- Enrollment target
Study Summary
This clinical trial is aimed at the evaluation of the safety and clinical activity of tiragolumab in combination with atezolizumab with or without chemotherapy in the first line treatment of metastatic non-squamous NSCLC patients with asymptomatic untreated brain metastases.
Primary Outcome
The proportion of patients that require salvage radiation therapy to the CNS (within 18 weeks from study initiation). Salvage radiation therapy is radiation treatment given for suspected recurrent malignant disease.
Interventions
- DRUG Carboplatin
- DRUG Atezolizumab
- DRUG Pemetrexed
- DRUG Tiragolumab
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 3 participants |
| Start Date | 2023-08-10 |
| Est. Completion | 2025-11-08 |
| Phase | Phase 2 |
Why NCT05746481 stopped before completion
NCT05746481 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 3 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 4 interventions - of which Carboplatin is the first listed.
NCT05746481 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05746481 about?
NCT05746481 is a clinical study titled "Tiragolumab and Atezolizumab in Patients With Non-squamous Non-small Cell Lung Cancer (NSCLC) and Untreated Brain Metastases". This clinical trial is aimed at the evaluation of the safety and clinical activity of tiragolumab in combination with atezolizumab with or without chemotherapy in the first line treatment of metastatic non-squamous NSCLC patients with asymptomatic untreated brain metastases.
What is the current status of trial NCT05746481?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 3 participants. The study started on 2023-08-10. Estimated completion is 2025-11-08.
What interventions are being tested in trial NCT05746481?
The interventions under investigation include: Carboplatin (DRUG), Atezolizumab (DRUG), Pemetrexed (DRUG), Tiragolumab (DRUG).
Who is sponsoring clinical trial NCT05746481?
This trial is sponsored by Liza Villaruz, MD, which has 5 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05746481's enrollment target sits among peer trials
3 2001st of 2000 the lowest of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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