Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
The Synergy Disc for the Treatment of 2 Level Cervical Degenerative Disc Disease Compared With Cervical Fusion Surgery
NCT05740176 · View on ClinicalTrials.gov ↗
Study Summary
A multicenter, prospective, non-randomized, historically controlled study. To demonstrate the Synergy Disc is at least as safe and effective as conventional anterior cervical discectomy and fusion (ACDF) to treat cervical degenerative disc disease (DDD) in subjects who are symptomatic at two levels from C3 to C7 are and are unresponsive to conservative management. Patients will be evaluated preoperatively, at the time of surgery, and at 6 weeks, and 3, 6, 12, and 24 months after surgery. Follow-up will continue annually until the last patient reaches 24-month follow-up. The primary analysis will occur at 24 months.
Conditions Studied
Interventions
- DEVICE Anterior Cervical Discectomy and Fusion
Study Locations (20)
California
- Todd Lanman, MD — Beverly Hills
- DOCS Health Management LLC — Los Angeles
- Institute of Neuro Innovation — Santa Monica
North Carolina
- Carolina NeuroSurgery and Spine Associates, PA — Charlotte
- M3 Emerging Medical Research — Durham
- Pinehurst Surgical Clinic — Pinehurst
Florida
- Brain and Spine Center of South Florida — Delray Beach
- Kennedy-White Orthopaedic Center — Sarasota
Indiana
- Indiana Spine Group — Carmel
- Orthopedics Northeast — Fort Wayne
Louisiana
- Bone and Joint Clinic of Baton Rouge — Baton Rouge
- Louisiana Spine Institute — Shreveport
Oregon
- Summit Spine — Portland
- Oregon Spine Care — Tualatin
Texas
- Austin Neurosurgeons — Austin
- DFW Center for Spinal Disorders — Fort Worth
Arizona
- HonorHealth — Scottsdale
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2023-06-01 |
| Est. Completion | 2026-12 |
| Phase | NA |
Interested in This Trial?
Always speak with your doctor before enrolling in a clinical trial.
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05740176
The ClinicalTrials.gov registry entry for NCT05740176 describes a study currently listed as active not recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 200 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Synergy Spine Solutions, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Cervical Degenerative Disc Disease appearing as the primary indexed condition, and to 1 intervention — of which Anterior Cervical Discectomy and Fusion is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05740176 reports 20 study locations spanning 11 distinct geographic areas — top geographies include California, North Carolina, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05740176 about?
NCT05740176 is a clinical study titled "The Synergy Disc for the Treatment of 2 Level Cervical Degenerative Disc Disease Compared With Cervical Fusion Surgery". A multicenter, prospective, non-randomized, historically controlled study. To demonstrate the Synergy Disc is at least as safe and effective as conventional anterior cervical discectomy and fusion (ACDF) to treat cervical degenerative disc disease (DDD) in subjects who are symptomatic at two levels ...
What is the current status of trial NCT05740176?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 200 participants. The study started on 2023-06-01. Estimated completion is 2026-12.
What conditions does trial NCT05740176 study?
This clinical trial studies the following conditions: Cervical Degenerative Disc Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05740176?
The interventions under investigation include: Anterior Cervical Discectomy and Fusion (DEVICE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05740176?
This trial is sponsored by Synergy Spine Solutions, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05740176 being conducted?
This trial has 20 study locations across Arizona, California, Colorado, Florida, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How Clinical Trials Work
Understand phases 1-4, trial design, randomization, and the informed consent process.
Patient Rights in Clinical Trials
Your rights as a participant: consent, withdrawal, privacy, and who to contact.
Finding the Right Clinical Trial
A practical guide to searching trials, understanding eligibility, and evaluating options.
All Guides
Browse our complete library of clinical trial educational resources.
Read our methodology — how this data is sourced, computed, and verified.