Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
DEFIANCE: RCT of ClotTriever System Versus Anticoagulation In Deep Vein Thrombosis
NCT05701917 · View on ClinicalTrials.gov ↗
Study Summary
This study is a prospective, multicenter, randomized controlled trial of an interventional strategy using the ClotTriever System to achieve and maintain vessel patency (ClotTriever Intervention Arm) versus conservative medical management using anticoagulation therapy alone (Conservative Medical Management Arm) in the treatment of subjects with symptomatic unilateral iliofemoral DVT. The study will collect data on demographics, comorbidities, details from the DVT diagnosis and treatment, and clinical outcomes through the 6-month follow up visit.
Conditions Studied
Interventions
- DEVICE ClotTriever System
- DRUG Commercially available/market approved anticoagulation medication including but not limited to: Heparin Sodium, Coumadin, Rivaroxaban, Apixaban, etc.
Study Locations (20)
Florida
- Manatee Memorial Hospital — Bradenton
- Baptist Health Research Institute — Jacksonville
- Lakeland Vascular Institute — Lakeland
- HCA Florida Largo Hospital — Largo
- Sarasota Memorial Hospital — Sarasota
- BayCare Health System — Tampa
Michigan
- McLaren Healthcare — Bay City
- Henry Ford Health — Detroit
- MyMichigan Medical Center — Midland
Arizona
- Honor Health — Scottsdale
- Pima Heart and Vascular — Tucson
California
- UCI Medical Center — Orange
- Vascular and Interventional Specialists of Orange County — Orange
Colorado
- University Of Colorado — Denver
Connecticut
- Yale University — New Haven
District of Columbia
- MedStar Health Research Institution — Washington D.C.
Georgia
- Memorial Health University Medical Center — Savannah
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 300 participants |
| Start Date | 2023-01-06 |
| Est. Completion | 2027-01-15 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05701917
The ClinicalTrials.gov registry entry for NCT05701917 describes a study currently listed as recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 300 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Inari Medical, which has 5 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 3 conditions, with Venous Thromboembolism appearing as the primary indexed condition, and to 2 interventions — of which ClotTriever System is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05701917 reports 20 study locations spanning 11 distinct geographic areas — top geographies include Florida, Michigan, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05701917 about?
NCT05701917 is a clinical study titled "DEFIANCE: RCT of ClotTriever System Versus Anticoagulation In Deep Vein Thrombosis". This study is a prospective, multicenter, randomized controlled trial of an interventional strategy using the ClotTriever System to achieve and maintain vessel patency (ClotTriever Intervention Arm) versus conservative medical management using anticoagulation therapy alone (Conservative Medical Mana...
What is the current status of trial NCT05701917?
This trial is currently recruiting. It is a NA study. The enrollment target is 300 participants. The study started on 2023-01-06. Estimated completion is 2027-01-15.
What conditions does trial NCT05701917 study?
This clinical trial studies the following conditions: Venous Thromboembolism, Deep Venous Thrombosis, Post-Thrombotic Syndrome. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05701917?
The interventions under investigation include: ClotTriever System (DEVICE), Commercially available/market approved anticoagulation medication including but not limited to: Heparin Sodium, Coumadin, Rivaroxaban, Apixaban, etc. (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05701917?
This trial is sponsored by Inari Medical, which has 5 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05701917 being conducted?
This trial has 20 study locations across Arizona, California, Colorado, Connecticut, District of Columbia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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