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NCT05694455 · ClinicalTrials.gov registry record · NA
Micro and Macro Circulation in Sepsis
A NA study, sponsored by Denver Health and Hospital Authority.
- Completed
- Registry status
- NA
- Development phase
- 68
- Enrollment target
NCT05694455: Completed NA study, sponsored by Denver Health and Hospital Authority.
NCT05694455 is a NA study that has completed, run by Denver Health and Hospital Authority. The registered enrollment target is 68 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05694455, a NA study, has completed, sponsored by Denver Health and Hospital Authority.
- COMPLETED
- Registry status
- NA
- Development phase
- 68 participants
- Enrollment target
Study Summary
Purpose: To assess the prognostic role of Handheld Vital Microscopy (HVM) and evaluate levels of endothelial glycocalyx (eGC) breakdown in patients demonstrating Hemodynamic Incoherence (HI), to elucidate a mechanistic link between the eGC and HI in order to inform prognostic enrichment of future resuscitation trials. We will serially evaluate microhemodynamics (MiH) and macro hemodynamics (maH) and the perfused boundary region (PBR, an visual proxy for eGC thickness) using HVM, and a validated circulating biomarker of eGC integrity.
Primary Outcome
Renal Replacement Therapy will be monitored while hospitalized for Sepsis/Septic Shock for initiation and days receiving Renal replacement will be counted.
Interventions
- OTHER Urine Collection
- DIAGNOSTIC_TEST Starling Stroke Volume (Starling SV)- Passive Leg Raise
- DIAGNOSTIC_TEST Microscan Sublingual Microscopy
- DIAGNOSTIC_TEST Venous Excess Ultrasound Scoring (VExUS)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 68 participants |
| Start Date | 2022-07-01 |
| Est. Completion | 2025-05-31 |
| Phase | NA |
What the finished NCT05694455 record still lists
NCT05694455 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 68 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 4 interventions - of which Urine Collection is the first listed.
NCT05694455 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05694455 about?
NCT05694455 is a clinical study titled "Micro and Macro Circulation in Sepsis". Purpose: To assess the prognostic role of Handheld Vital Microscopy (HVM) and evaluate levels of endothelial glycocalyx (eGC) breakdown in patients demonstrating Hemodynamic Incoherence (HI), to elucidate a mechanistic link between the eGC and HI in order to inform prognostic enrichment of future re...
What is the current status of trial NCT05694455?
This trial is currently completed. It is a NA study. The enrollment target is 68 participants. The study started on 2022-07-01. Estimated completion is 2025-05-31.
What interventions are being tested in trial NCT05694455?
The interventions under investigation include: Urine Collection (OTHER), Starling Stroke Volume (Starling SV)- Passive Leg Raise (DIAGNOSTIC_TEST), Microscan Sublingual Microscopy (DIAGNOSTIC_TEST), Venous Excess Ultrasound Scoring (VExUS) (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT05694455?
This trial is sponsored by Denver Health and Hospital Authority, which has 73 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05694455's enrollment target sits among peer trials
68 1133rd of 2000 higher than 862 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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