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NCT05694455 · ClinicalTrials.gov registry record · NA
Micro and Macro Circulation in Sepsis
A NA study, sponsored by Denver Health and Hospital Authority.
- Completed
- Registry status
- NA
- Development phase
- 68
- Enrollment target
NCT05694455 is a NA study that has completed, run by Denver Health and Hospital Authority. The registered enrollment target is 68 participants.
The verdict
NCT05694455, a NA study, has completed, sponsored by Denver Health and Hospital Authority.
- COMPLETED
- Registry status
- NA
- Development phase
- 68 participants
- Enrollment target
Study Summary
Purpose: To assess the prognostic role of Handheld Vital Microscopy (HVM) and evaluate levels of endothelial glycocalyx (eGC) breakdown in patients demonstrating Hemodynamic Incoherence (HI), to elucidate a mechanistic link between the eGC and HI in order to inform prognostic enrichment of future resuscitation trials. We will serially evaluate microhemodynamics (MiH) and macro hemodynamics (maH) and the perfused boundary region (PBR, an visual proxy for eGC thickness) using HVM, and a validated circulating biomarker of eGC integrity.
Interventions
- OTHER Urine Collection
- DIAGNOSTIC_TEST Starling Stroke Volume (Starling SV)- Passive Leg Raise
- DIAGNOSTIC_TEST Microscan Sublingual Microscopy
- DIAGNOSTIC_TEST Venous Excess Ultrasound Scoring (VExUS)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 68 participants |
| Start Date | 2022-07-01 |
| Est. Completion | 2025-05-31 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05694455
The ClinicalTrials.gov registry entry for NCT05694455 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 68 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Denver Health and Hospital Authority, which has 73 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 4 interventions - of which Urine Collection is the first listed.
NCT05694455 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT05694455 about?
NCT05694455 is a clinical study titled "Micro and Macro Circulation in Sepsis". Purpose: To assess the prognostic role of Handheld Vital Microscopy (HVM) and evaluate levels of endothelial glycocalyx (eGC) breakdown in patients demonstrating Hemodynamic Incoherence (HI), to elucidate a mechanistic link between the eGC and HI in order to inform prognostic enrichment of future re...
What is the current status of trial NCT05694455?
This trial is currently completed. It is a NA study. The enrollment target is 68 participants. The study started on 2022-07-01. Estimated completion is 2025-05-31.
What interventions are being tested in trial NCT05694455?
The interventions under investigation include: Urine Collection (OTHER), Starling Stroke Volume (Starling SV)- Passive Leg Raise (DIAGNOSTIC_TEST), Microscan Sublingual Microscopy (DIAGNOSTIC_TEST), Venous Excess Ultrasound Scoring (VExUS) (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT05694455?
This trial is sponsored by Denver Health and Hospital Authority, which has 73 total clinical trials registered on ClinicalTrials.gov.
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