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NCT05684978 · ClinicalTrials.gov registry record · Phase 4
Efficacy and Safety of Perampanel in the Treatment of Refractory Status Epilepticus
A Phase 4 study, sponsored by Wayne State University.
- Terminated
- Registry status
- Phase 4
- Development phase
- 1
- Enrollment target
NCT05684978: Clinical Trial Phase 4 study, sponsored by Wayne State University.
NCT05684978 is a Phase 4 study that was terminated before completion, run by Wayne State University. The registered enrollment target is 1 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (100% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05684978, a Phase 4 study, was terminated before completion, sponsored by Wayne State University.
- TERMINATED
- Registry status
- Phase 4
- Development phase
- 1 participants
- Enrollment target
Study Summary
This project is aiming to better understand the use of perampanel as an appropriate standard-of-care therapy for treatment refractory status epilepticus (RSE), to identify determinants of outcomes, and establish safety. The study will recruit 25 patients at WSU. The study will last for about 96 weeks and will involve a screening visit and two in clinic visits at 3 and 6 months. If the subjects give written informed consent and meet all eligibility criteria they will be clinically evaluated and will be given the study drug. This study will involve recording of patients medical history, drug history and epilepsy history. A physical exam and a and neurological exam will also be performed to study the heath status of the participant. Results and patient information will be stored in a database for analysis to find commonality among key factors that have been seen in past research.
Primary Outcome
Successful wean of IV anesthetics without recurrence of status epilepticus. a. Determined by absence of clinical and electrographic seizure activity.
Interventions
- DRUG Perampanel
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1 participants |
| Start Date | 2025-10-10 |
| Est. Completion | 2025-10-10 |
| Phase | Phase 4 |
Why NCT05684978 stopped before completion
NCT05684978 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 1 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (100% lower).
The record links to 0 conditions, and to 1 intervention - of which Perampanel is the first listed.
NCT05684978 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05684978 about?
NCT05684978 is a clinical study titled "Efficacy and Safety of Perampanel in the Treatment of Refractory Status Epilepticus". This project is aiming to better understand the use of perampanel as an appropriate standard-of-care therapy for treatment refractory status epilepticus (RSE), to identify determinants of outcomes, and establish safety. The study will recruit 25 patients at WSU. The study will last for about 96 week...
What is the current status of trial NCT05684978?
This trial is currently terminated. It is a Phase 4 study. The enrollment target is 1 participants. The study started on 2025-10-10. Estimated completion is 2025-10-10.
What interventions are being tested in trial NCT05684978?
The interventions under investigation include: Perampanel (DRUG).
Who is sponsoring clinical trial NCT05684978?
This trial is sponsored by Wayne State University, which has 163 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05684978's enrollment target sits among peer trials
1 2000th of 2000 the lowest of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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